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PROSITE documentation PDOC51046 [for PROSITE entry PS51046]

GON domain profile





Description

The ADAMTSs (a disintegrin and metalloproteinase domain with thrombospondin type-1 modules) are a family of zinc dependent metalloproteinases that play important roles in a variety of normal and pathological conditions. These enzymes show a complex domain organization including signal sequence, propeptide, metalloproteinase domain (see <PDOC50215>), disintegrin-like domain (see <PDOC00351>), central TS-1 motif (see <PDOC50092>), cysteine-rich region, and a variable number of TS-like repeats at the C-terminal region. The GON domain is a ~200-residue module, whose presence is a hallmark of a subfamily of structurally and evolutionarily related ADAMTSs, called GON-ADAMTSs. The GON domain is characterized by the presence of several conserved cysteine residues and is likely to be globular [1,2].

Some proteins known to contain a GON domain are listed below:

  • Mammalian ADAMTS-9.
  • Mammalian ADAMTS-20.
  • Caenorhabditis elegans gon-1, a protease required for gonadal morphogenesis.

The profile we developed covers the entire GON domain.

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html --------------------------------------------------------------------------------.

Last update:

December 2004 / First entry.

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Technical section

PROSITE method (with tools and information) covered by this documentation:

GON, PS51046; GON domain profile  (MATRIX)


References

1AuthorsLlamazares M. Cal S. Quesada V. Lopez-Otin C.
TitleIdentification and characterization of ADAMTS-20 defines a novel subfamily of metalloproteinases-disintegrins with multiple thrombospondin-1 repeats and a unique GON domain.
SourceJ. Biol. Chem. 278:13382-13389(2003).
PubMed ID12562771
DOI10.1074/jbc.M211900200;

2AuthorsSomerville R.P.T. Longpre J.-M. Jungers K.A. Engle J.M. Ross M. Evanko S. Wight T.N. Leduc R. Apte S.S.
TitleCharacterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1.
SourceJ. Biol. Chem. 278:9503-9513(2003).
PubMed ID12514189
DOI10.1074/jbc.M211009200



PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

Miscellaneous

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