The WSC domain is a putative carbohydrate binding domain of about 90 amino
acids. The domain is named after yeast WSC1-WSC4 (cell wall integrity and
stress response components 1-4) proteins, which each contain a single WSC
domain. The WSC domain can also be found as more copies in tandem or in
combination with other domains, such as PKD (see <PDOC50093>), LDL-receptor
class A (see<PDOC00929>), C-type lectin (see <PDOC00537>); kringle (see
<PDOC00020>), CUB (see <PDOC00908>); FN3 (see <PDOC50853>) and protein kinase
(see <PDOC00100>). The WSC domain contains eight conserved cysteine residues
which are predicted to form disulfide bridges .
Some proteins known to contain a WSC domain:
Mammalian polycystin-1 (PKD1), which forms a calcium-regulated ion channel
with PKD2. Defects in PKD1 are the cause of autosomal dominant polycystic
kidney disease type I.
Baker's yeast SLG1/WSC1, WSC2 and WSC3 proteins, which may act as sensors
of environmental stress.
Baker's yeast WSC4, which is implicated in protein translocation to the
Mammalian kremen (kringle-containing protein marking the eye and the nose)
proteins 1 and 2.
Fruit fly xylosyltransferase oxt (EC 126.96.36.199), which is the first
glycosyltransferase in the biosynthesis of glycosaminoglycan chains.
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