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PROSITE documentation PDOC51227 [for PROSITE entry PS51227]

Sprouty (SPR) domain profile





Description

Sprouty (Spry) and Spred (Sprouty related EVH1 domain) proteins have been identified as inhibitors of the Ras/mitogen-activated protein kinase (MAPK) cascade, a pathway crucial for developmental processes initiated by activation of various receptor tyrosine kinases [1,2]. These proteins share a conserved, C-terminal cysteine-rich region, the SPR domain. This domain has been defined as a novel cytosol to membrane translocation domain [1,2,3,4]. It has been found to be a PtdIns(4,5)P2-binding domain that targets the proteins to a cellular localization that maximizes their inhibitory potential [5,6]. It also mediates homodimer formation of these proteins [1,5].

The SPR domain can occur in association with the WH1 domain (see <PDOC50229>) (located in the N-terminal part of the proteins) in the Spred proteins.

We developed a profile that spans the entire SPR domain.

Note:

The SPR domain is also named Spry translocation domain (SpryTD).

Last update:

July 2006 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

SPR, PS51227; Sprouty (SPR) domain profile  (MATRIX)


References

1AuthorsKing J.A.J. Straffon A.F.L. D'Abaco G.M. Poon C.L.C. I S.T.T. Smith C.M. Buchert M. Corcoran N.M. Hall N.E. Callus B.A. Sarcevic B. Martin D. Lock P. Hovens C.M.
TitleDistinct requirements for the Sprouty domain for functional activity of Spred proteins.
SourceBiochem. J. 388:445-454(2005).
PubMed ID15683364
DOI10.1042/BJ20041284

2AuthorsLim J. Yusoff P. Wong E.S.M. Chandramouli S. Lao D.-H. Fong C.W. Guy G.R.
TitleThe cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes.
SourceMol. Cell. Biol. 22:7953-7966(2002).
PubMed ID12391162

3AuthorsLim J. Wong E.S.M. Ong S.H. Yusoff P. Low B.C. Guy G.R.
TitleSprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain.
SourceJ. Biol. Chem. 275:32837-32845(2000).
PubMed ID10887178
DOI10.1074/jbc.M002156200

4AuthorsWakioka T. Sasaki A. Kato R. Shouda T. Matsumoto A. Miyoshi K. Tsuneoka M. Komiya S. Baron R. Yoshimura A.
TitleSpred is a Sprouty-related suppressor of Ras signalling.
SourceNature 412:647-651(2001).
PubMed ID11493923
DOI10.1038/35088082

5AuthorsHanafusa H. Torii S. Yasunaga T. Nishida E.
TitleSprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.
SourceNat. Cell Biol. 4:850-858(2002).
PubMed ID12402043
DOI10.1038/ncb867

6AuthorsLim J. Yusoff P. Wong E.S.M. Chandramouli S. Lao D.-H. Fong C.W. Guy G.R.
TitleThe cysteine-rich sprouty translocation domain targets mitogen-activated protein kinase inhibitory proteins to phosphatidylinositol 4,5-bisphosphate in plasma membranes.
SourceMol. Cell. Biol. 22:7953-7966(2002).
PubMed ID12391162



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