PROSITE documentation PDOC51358 [for PROSITE entry PS51358]
Nop domain profile
The ~120-residue Nop domain is present in various pre-RNA processing
Eukaryotic Prp31, part of a tri-snRNP complex. It is involved in pre-mRNA
Eukaryotic Nucleolar proteins 56 and 58 (Nop56 and Nop58), components of
box C/D small nucleolar ribonucleoprotein (snoRNP) particles.
Archaeal Nop5, an homolog of Nop56/Nop58.
The Nop domain is a RNP binding module, exhibiting RNA and protein binding
surfaces. It is oval-shaped and exclusively α-helical (see <PDB:
[ 1, 2].
The profile we developed covers the entire Nop domain.
June 2012 / First entry.
PROSITE method (with tools and information) covered by this documentation:
PS51358; Nop domain profile (MATRIX)
1 Authors Aittaleb M., Rashid R., Chen Q., Palmer J.R., Daniels C.J., Li H.
Title Structure and function of archaeal box C/D sRNP core proteins.
Source Nat. Struct. Biol. 10:256-263(2003).
PubMed ID 12598892
2 Authors Liu S., Li P., Dybkov O., Nottrott S., Hartmuth K., Luehrmann R., Carlomagno T., Wahl M.C.
Title Binding of the human Prp31 Nop domain to a composite RNA-protein platform in U4 snRNP.
Source Science 316:115-120(2007).
PubMed ID 17412961
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