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PROSITE documentation PDOC51377 [for PROSITE entry PS51377] |
The KIND (kinase non-catalytic C-lobe domain) is a putative protein interaction domain, which has been identified as being similar to the C-terminal protein kinase catalytic fold (C lobe) (see <PDOC00100>). Its presence at the N-terminus of signalling proteins and the absence of the active site residues in the catalytic and activation loops suggest that it folds independently and is likely to be non-catalytic. The occurence of the domain only in metazoa implies that it has evolved from the catalytic protein kinase domain into an interaction domain possibly by keeping the substrate-binding features [1,2].
Some proteins known to contain a KIND domain are listed below:
The profile we developed covers the entire KIND domain.
Last update:April 2008 / First entry.
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PROSITE method (with tools and information) covered by this documentation:
1 | Authors | Ciccarelli F.D. Bork P. Kerkhoff E. |
Title | The KIND module: a putative signalling domain evolved from the C lobe of the protein kinase fold. | |
Source | Trends Biochem. Sci. 28:349-352(2003). | |
PubMed ID | 12877999 |
2 | Authors | Mees A. Rock R. Ciccarelli F.D. Leberfinger C.B. Borawski J.M. Bork P. Wiese S. Gessler M. Kerkhoff E. |
Title | Very-KIND is a novel nervous system specific guanine nucleotide exchange factor for Ras GTPases. | |
Source | Gene Expr. Patterns 6:79-85(2005). | |
PubMed ID | 16099729 | |
DOI | 10.1016/j.modgep.2005.04.015 |