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PROSITE documentation PDOC51381 [for PROSITE entry PS51381]

B9 domain profile


B9 domain containing proteins are found in flagellar or cilia-containing species. Although its function is unknown, a cilia-specific role has been suggested for the poorly characterized B9 domain [1,2,3].

Some proteins known to contain a B9 domain are listed below:

  • Mammalian Meckel syndrome 1 (MKS1) protein, which may be related to the ciliary basal body.
  • Mammalian protein B9D1 and B9D2.
  • Caenorhabditis elegans X-box promoter element regulated protein 7 (xbx-7). It corresponds to mammalian MKS1.
  • Caenorhabditis elegans ciliary transition zone associate protein 1 (tza-1). It corresponds to mammalian B9D2.
  • Caenorhabditis elegans ciliary transition zone associate protein 2 (tza-2). It corresponds to mammalian B9D1.
  • Paramecium tetraurelia ICIS-1 (Involved in Cilia Stability-1), the B9D2 homolog.

The profile we developed covers the entire B9 domain.

Last update:

May 2008 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

B9, PS51381; B9 domain profile  (MATRIX)


1AuthorsKyttaelae M. Tallila J. Salonen R. Kopra O. Kohlschmidt N. Paavola-Sakki P. Peltonen L. Kestilae M.
TitleMKS1, encoding a component of the flagellar apparatus basal body proteome, is mutated in Meckel syndrome.
SourceNat. Genet. 38:155-157(2006).
PubMed ID16415886

2AuthorsPonsard C. Skowron-Zwarg M. Seltzer V. Perret E. Gallinger J. Fisch C. Dupuis-Williams P. Caruso N. Middendorp S. Tournier F.
TitleIdentification of ICIS-1, a new protein involved in cilia stability.
SourceFront. Biosci. 12:1661-1669(2007).
PubMed ID17127412

3AuthorsWilliams C.L. Winkelbauer M.E. Schafer J.C. Michaud E.J. Yoder B.K.
TitleFunctional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis.
SourceMol. Biol. Cell. 19:2154-2168(2008).
PubMed ID18337471

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