The PUL (after PLAP, UFD3 and lub1) domain is a predicted predominantly α
helical globular domain found in eukaryotes. It is found in association with
either WD repeats (see <PDOC00574>) and the PFU domain (see <PDOC51394>) or
PPPDE and thioredoxin (see <PDOC00172>) domains. The PUL domain is a protein-protein interaction domain [1,2].
Some proteins known to contain a PUL domain are listed below:
Saccharomyces cerevisiae DOA1 (UFD3, ZZZ4), involved in ubiquitin
conjugation pathway. DOA1 participates in the regulation of the ubiquitin
conjugation pathway involving CDC48 by hindering multiubiquitination of
substrates at the CDC48 chaperone.
Schizosaccharomyces pombe ubiquitin homeostasis protein lub1, acts as a
negative regulator of vacuole-dependent ubiquitin degradation.
Mammalian phospholipase A-2-activating protein (PLA2P, PLAA), the homologue
of DOA1. PLA2P plays an important role in the regulation of specific
inflammatory disease processes.
The profile we developed covers the entire PUL domain.
July 2008 / First entry.
PROSITE method (with tools and information) covered by this documentation:
Iyer L.M. Koonin E.V. Aravind L.
Novel predicted peptidases with a potential role in the ubiquitin signaling pathway.
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