PROSITE documentation PDOC51545 [for PROSITE entry PS51545]

Phosphatidylinositol kinase (PIK) helical domain profile





Description

Phosphatidylinositol kinases are found in all eukaryotes and serve important functions in phosphatidylinositol (PI) signaling pathways. All PI3Ks and PI4Ks contain a conserved PI-kinase domain (see <PDOC00710>), and most have various additional domains that are involved in protein-protein or phospholipid-protein interactions [1,2]. The phosphoinositide kinase (PIK) domain is a region conserved among all PI3 and PI4-kinases and although its role is presently unclear, it is likely to be involved in substrate presentation [3].

The PIK domain folds as an all α-helical structure (see <PDB:2RD0>) [4].

The profile we developed covers the entire PIK helical domain.

Last update:

August 2011 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

PIK_HELICAL, PS51545; PIK helical domain profile  (MATRIX)


References

1AuthorsBosotti R., Isacchi A., Sonnhammer E.L.
TitleFAT: a novel domain in PIK-related kinases.
SourceTrends Biochem. Sci. 25:225-227(2000).
PubMed ID10782091

2AuthorsMeijer H.J.G., Govers F.
TitleGenomewide analysis of phospholipid signaling genes in Phytophthora spp.: novelties and a missing link.
SourceMol. Plant Microbe Interact. 19:1337-1347(2006).
PubMed ID17153918
DOI10.1094/MPMI-19-1337

3AuthorsDomin J., Waterfield M.D.
TitleUsing structure to define the function of phosphoinositide 3-kinase family members.
SourceFEBS Lett. 410:91-95(1997).
PubMed ID9247130

4AuthorsHuang C.-H., Mandelker D., Schmidt-Kittler O., Samuels Y., Velculescu V.E., Kinzler K.W., Vogelstein B., Gabelli S.B., Amzel L.M.
TitleThe structure of a human p110alpha/p85alpha complex elucidates the effects of oncogenic PI3Kalpha mutations.
SourceScience 318:1744-1748(2007).
PubMed ID18079394
DOI10.1126/science.1150799



PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to
Prosite License or see: prosite_license.html.

Miscellaneous

View entry in original PROSITE document format
View entry in raw text format (no links)