Phosphatidylinositol kinases are found in all eukaryotes and serve important
functions in phosphatidylinositol (PI) signaling pathways. All PI3Ks and PI4Ks
contain a conserved PI-kinase domain (see <PDOC00710>), and most have various
additional domains that are involved in protein-protein or phospholipid-protein interactions [1,2]. The phosphoinositide kinase (PIK) domain is a
region conserved among all PI3 and PI4-kinases and although its role is
presently unclear, it is likely to be involved in substrate presentation .
The PIK domain folds as an all α-helical structure (see <PDB:2RD0>) .
The profile we developed covers the entire PIK helical domain.
August 2011 / First entry.
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