PROSITE documentation PDOC51666 [for PROSITE entry PS51666]

QLQ domain profile


The QLQ domain is characterized by the conserved Gln-Leu-Gln residues. Another feature of this domain is the absolute conservation of bulky aromatic/hydrophobic and acidic amino acid residues such as Phe, Trp, Tyr, Leu, Glu, or their equivalents in terms of chemical and radial properties. The Pro residue is also absolutely conserved. These amino acid residues are critical for the function of the QLQ domain, probably for protein-protein interaction [1].

Some proteins known to conatin a QLQ domain are listed below:

  • Plant GROWTH-REGULATING FACTOR (GRF) proteins, putative transcription factors.
  • Eukaryotic SWI2/SNF2, transcriptional coactivators.

The QLQ domain might be involved in protein-protein interaction [1].

The profile we developed covers the entire QLQ domain.

Last update:

February 2013 / First entry.

Technical section

PROSITE method (with tools and information) covered by this documentation:

QLQ, PS51666; QLQ domain profile  (MATRIX)


1AuthorsKim J.H., Choi D., Kende H.
TitleThe AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis.
SourcePlant J. 36:94-104(2003).
PubMed ID12974814

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to
Prosite License or see: prosite_license.html.


View entry in original PROSITE document format
View entry in raw text format (no links)