Glycoside hydrolases (GHs) play a critical role in both eukaryotes and
prokaryotes, where they fulfill numerous important functions such as substrate
acquisition and the remote remodelling of cell walls and the glycan
decorations of glycoproteins. GH family 26 consists mainly of endo-β-1,4-mannanases (mannanases), although some members of this family display β-1,3-xylanase activity. The family 26 GHs are members of clan GH-A
The GH26 catalytic domain exhibits the architecture of the classical
(β/α)8-barrel folding motif characteristic of a clan-GH-A member
(see <PDB:2BVY>). Two Glu residues located respectively on strands β-4 and
β-7 act as the catalytic acid/base and nucleophile in a double-displacement
The profile we developed covers the entire GH26 domain.
July 2015 / First entry.
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