PROSITE documentation PDOC51823 [for PROSITE entry PS51823]
Clueless (Clu) domain profile


The protein Clueless (Clu) is a large multi-domain protein that is highly conserved and directly required for mitochondrial function. Clu is involved in binding and directing nuclear encoded mitochondrially destined mRNAs to the mitochondrial outer membrane and potentially positioning them for co-translational import. Clu may act as a type of scaffold that can bring together several mechanisms in order to maintain mitochondrial function and output. Clu-related proteins are highly conserved and share a ~245-amino acid region (the 'Clu domain') and TPR repeats (see <PDOC50005>) [1,2,3].

The profile we developed covers the entire Clu domain.

Last update:

December 2016 / First entry.


Technical section

PROSITE method (with tools and information) covered by this documentation:

CLU, PS51823; Clueless (Clu) domain profile  (MATRIX)


1AuthorsCox R.T. Spradling A.C.
TitleClueless, a conserved Drosophila gene required for mitochondrial subcellular localization, interacts genetically with parkin.
SourceDis. Model. Mech. 2:490-499(2009).
PubMed ID19638420

2AuthorsSen A. Kalvakuri S. Bodmer R. Cox R.T.
TitleClueless, a protein required for mitochondrial function, interacts with the PINK1-Parkin complex in Drosophila.
SourceDis. Model. Mech. 8:577-589(2015).
PubMed ID26035866

3AuthorsSen A. Cox R.T.
TitleClueless is a conserved ribonucleoprotein that binds the ribosome at the mitochondrial outer membrane.
SourceBiol. Open 5:195-203(2016).
PubMed ID26834020

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