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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00024


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00024
General rule information [?]

Accession PRU00024
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 17)
Data class Domain;
Predictors PROSITE; PS50119; ZF_BBOX
Name Zinc finger B-box-type
Function It is found essentially in transcription factors, ribonucleoproteins and proto-oncoproteins, but no function is clearly assigned to this domain.
Scope(s) Eukaryota
Example(s) Q92021;

Propagated annotation [?]

Keywords [?]

Zinc-finger
case <Feature:PS50119:6=[CH]> and <Feature:PS50119:9=[CH]> and <Feature:PS50119:29=[CH]> and <Feature:PS50119:35=[CH]>
Zinc
Metal-binding
end case

Features [?]

From: PS50119
Key From To Description Tag Condition FTGroup
case <Feature:PS50119:6=[C]> and <Feature:PS50119:9=[H]> and <Feature:PS50119:29=[C]> and <Feature:PS50119:35=[H]>
ZN_FING from to /note="B box-type #"
else case <Feature:PS50119:6=[CH]> and <Feature:PS50119:9=[CH]> and <Feature:PS50119:29=[CH]> and <Feature:PS50119:35=[CH]>
ZN_FING from to /note="B box-type #; atypical"
else
ZN_FING from to /note="B box-type #; degenerate"
end case
BINDING 6 6 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 9 9 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 29 29 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1
BINDING 35 35 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 1

Additional information [?]

Size range 31-54 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]