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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00041


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00041
General rule information [?]

Accession PRU00041
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 16)
Data class Domain;
Predictors PROSITE; PS50004; C2
Name C2 domain
Function The C2 domain is thought to be involved in calcium-dependent phospholipid binding.
Scope(s) Eukaryota
Example(s) Q6XYQ8;

Propagated annotation [?]

Comments [?]

case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
COFACTOR Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per C2 domain.
else case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
COFACTOR Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
end case

Keywords [?]

Metal-binding
Calcium
end case

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
GO:0005509; Molecular function:calcium ion binding

Features [?]

From: PS50004
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="C2 #"
case <FTGroup:2>
BINDING 33 33 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"		 L 2
end case
BINDING 34 34 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 D 1
BINDING 34 34 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"		 D 2
BINDING 40 40 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 D 1
BINDING 90 90 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 D 1
BINDING 90 90 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"		 D 2
case <FTGroup:1>
BINDING 91 91 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 F
end case
BINDING 92 92 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 D 1
BINDING 92 92 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"		 D 2
BINDING 92 92 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#3"		 D 3
BINDING 95 95 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#3"		 S 3
case <FTGroup:3>
BINDING 96 96 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#3"		 K 3
end case
BINDING 98 98 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"		 D 2
BINDING 98 98 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#3"		 D 3

Additional information [?]

Size range 16-133 amino acids
Related rules None
Fusion None
Repeats 1-5
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]