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ProRule PRU00041


General rule information [?]

Accession PRU00041
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 15)
Data class Domain;
Predictors PROSITE; PS50004; C2
Name C2 domain
Function The C2 domain is thought to be involved in calcium-dependent phospholipid binding.
Scope(s) Eukaryota
Example(s) Q6XYQ8 (SYT10_HUMAN);

Propagated annotation [?]

Comments [?]

case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
COFACTOR Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per C2 domain.
else case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
COFACTOR Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
end case

Keywords [?]

Metal-binding
Calcium
end case

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
GO:0005509; Molecular function:calcium ion binding

Features [?]

From: PS50004
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="C2 #"
case <FTGroup:2>
BINDING 33 33 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"		 L 2
end case
BINDING 34 34 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 D 1
BINDING 34 34 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"		 D 2
BINDING 40 40 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 D 1
BINDING 90 90 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 D 1
BINDING 90 90 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"		 D 2
case <FTGroup:1>
BINDING 91 91 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 F
end case
BINDING 92 92 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 D 1
BINDING 92 92 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"		 D 2
BINDING 92 92 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#3"		 D 3
BINDING 95 95 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#3"		 S 3
case <FTGroup:3>
BINDING 96 96 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#3"		 K 3
end case
BINDING 98 98 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#2"		 D 2
BINDING 98 98 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#3"		 D 3

Additional information [?]

Size range 16-133 amino acids
Related rules None
Fusion None
Repeats 1-5
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]