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annotation rule: PRU00041

General rule information [?]

Accession PRU00041
Dates 12-DEC-2003 (Created)
3-JAN-2020 (Last updated, Version 13)
Data class Domain
Predictors PROSITE; PS50004; C2
Name C2 domain
Function The C2 domain is thought to be involved in calcium-dependent phospholipid binding.

Propagated annotation [?]


Comments [?]

case <FTGroup:1> and <FTGroup:2> and <FTGroup:3>
Cofactor Ca(2+)
Note: Binds 3 Ca(2+) ions per C2 domain
else case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
Cofactor Ca(2+)
end case


Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2> or <FTGroup:3>
GO:0005509; Molecular function: calcium ion binding.

Keywords [?]

end case


Features [?]

From: PS50004
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       C2 #        
case <FTGroup:2>
METAL     33     33       Calcium #2; via carbonyl oxygen     L   2
end case

METAL     34     34       Calcium #1     D   1
METAL     34     34       Calcium #2     D   2
METAL     40     40       Calcium #1     D   1
METAL     90     90       Calcium #1     D   1
METAL     90     90       Calcium #2     D   2
case <FTGroup:1>
METAL     91     91       Calcium #1; via carbonyl oxygen     F  
end case

METAL     92     92       Calcium #1     D   1
METAL     92     92       Calcium #2     D   2
METAL     92     92       Calcium #3     D   3
METAL     95     95       Calcium #3     S   3
case <FTGroup:3>
METAL     96     96       Calcium #3; via carbonyl oxygen     K   3
end case

METAL     98     98       Calcium #2     D   2
METAL     98     98       Calcium #3     D   3

Additional information [?]

Size range 16-133 amino acids
Related rules None
Repeats 1-5
Topology Undefined
Example Q6XYQ8 (SYT10_HUMAN)
Scope
Eukaryota

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]

UniProtKB/Swiss-Prot sets
Eukaryota [654]