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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00076


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00076
General rule information [?]

Accession PRU00076
Dates 12-DEC-2003 (Created)
20-NOV-2019 (Last updated, Version 20)
Data class Domain;
Predictors PROSITE; PS50026; EGF_3
Name EGF-like domain
Function Undefined
Scope(s) Eukaryota
Viruses
Chordopoxvirinae
Example(s) P01135;

Propagated annotation [?]

Keywords [?]

case <Feature:PS50026:1-17=[DEQN]-x-[DEQN](2)-C-x(3,14)-C-x(3,7)-C-x-[DN]>
Calcium
end case
EGF-like domain
case <FTTag:disulf>
Disulfide bond
end case

Gene Ontology [?]

case <Feature:PS50026:1-17=[DEQN]-x-[DEQN](2)-C-x(3,14)-C-x(3,7)-C-x-[DN]>
GO:0005509; Molecular function:calcium ion binding
end case

Cross-references [?]

PROSITE PS00022; EGF_1; 1;
PROSITE PS01186; EGF_2; 1;
PROSITE PS01187; EGF_CA; 0-1;

Features [?]

From: PS50026
Key From To Description Tag Condition FTGroup
case <Feature:PS50026:1-17=[DEQN]-x-[DEQN](2)-C-x(3,14)-C-x(3,7)-C-x-[DN]>
DOMAIN from to /note="EGF-like #; calcium-binding"
else
DOMAIN from to /note="EGF-like #"
end case
DISULFID 5 15 disulf C-x*-C
DISULFID 9 26 disulf C-x*-C
DISULFID 28 37 disulf C-x*-C

Additional information [?]

Size range 13-99 amino acids
Related rules None
Fusion None
Repeats 1-52
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]