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ProRule PRU00160


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU00160
Accession PRU00160
Dates 12-DEC-2003 (Created)
7-MAY-2020 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS50054; TYR_PHOSPHATASE_DUAL
PROSITE; PS50055; TYR_PHOSPHATASE_PTP
Name Protein-tyrosine phosphatase domain
Function Tyrosine specific protein phosphatases (EC 3.1.3.48) (PTPase) are enzymes that catalyze the removal of a phosphate group attached to a tyrosine residue.
Scope(s) Eukaryota
Example(s) P23469 (PTPRE_HUMAN); Q6NKR2 (TPMT2_ARATH);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTTag:act_site>
Protein name + RecName: EC=3.1.3.-;

Keywords [?]

Protein phosphatase
Hydrolase
end case

Gene Ontology [?]

case <FTTag:act_site>
GO:0008138; Molecular function:protein tyrosine/serine/threonine phosphatase activity
GO:0004725; Molecular function:protein tyrosine phosphatase activity
GO:0016787; Molecular function:hydrolase activity

Cross-references [?]

PROSITE PS00383; TYR_PHOSPHATASE_1; 1;
PROSITE PS50056; TYR_PHOSPHATASE_2; 1;

Features [?]

From: any
Key From To Description Tag Condition FTGroup
case <Feature:PS50054>
DOMAIN from to /note="Tyrosine-protein phosphatase #"
ACT_SITE 89 89 /note="Phosphocysteine intermediate" act_site C
else case <Feature:PS50055>
DOMAIN from to /note="Tyrosine-protein phosphatase #"
ACT_SITE 196 196 /note="Phosphocysteine intermediate" act_site C
end case

Additional information [?]

Size range 63-419 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

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UniProtKB rule member sequences [?]