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annotation rule: PRU00160

General rule information [?]

Accession PRU00160
Dates 12-DEC-2003 (Created)
7-MAY-2020 (Last updated, Version 13)
Data class Domain
Predictors PROSITE; PS50054; TYR_PHOSPHATASE_DUAL
Predictors PROSITE; PS50055; TYR_PHOSPHATASE_PTP
Name Protein-tyrosine phosphatase domain
Function Tyrosine specific protein phosphatases (EC 3.1.3.48) (PTPase) are enzymes that catalyze the removal of a phosphate group attached to a tyrosine residue.

Propagated annotation [?]


Description [?]

case <FTTag:act_site>
+ RecName: EC 3.1.3.-;

Cross-references [?]

PROSITE PS00383; TYR_PHOSPHATASE_1; 1;
end case

PROSITE PS50056; TYR_PHOSPHATASE_2; 1;

Gene Ontology [?]

case <FTTag:act_site>
GO:0008138; Molecular function: protein tyrosine/serine/threonine phosphatase activity.
GO:0004725; Molecular function: protein tyrosine phosphatase activity.
GO:0016787; Molecular function: hydrolase activity.

Keywords [?]

Protein phosphatase
Hydrolase
end case


Features [?]

case <Feature:PS50054>
From: any
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Tyrosine-protein phosphatase #        
ACT_SITE     89     89       Phosphocysteine intermediate   act_site   C  
else case <Feature:PS50055>
DOMAIN     from     to       Tyrosine-protein phosphatase #        
ACT_SITE     196     196       Phosphocysteine intermediate   act_site   C  
end case


Additional information [?]

Size range 63-419 amino acids
Related rules None
Repeats 1-2
Topology Undefined
Examples P23469 (PTPRE_HUMAN); Q6NKR2 (TPMT2_ARATH): [Recover all]
Scope
Eukaryota

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]