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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00175


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00175
General rule information [?]

Accession PRU00175
Dates 12-DEC-2003 (Created)
20-NOV-2019 (Last updated, Version 15)
Data class Domain;
Predictors PROSITE; PS50089; ZF_RING_2
Name Zinc finger RING-type
Function It has been shown that several RING fingers act as E3 enzymes in the ubiquitination process.
Scope(s) Eukaryota
Viruses
Example(s) Q9M0R4;

Propagated annotation [?]

Keywords [?]

Zinc-finger
case (<Feature:PS50089:1=[CH]> and <Feature:PS50089:4=[CH]> and <Feature:PS50089:23=[CH]> and <Feature:PS50089:26=[CH]>) or (<Feature:PS50089:18=[CH]> and <Feature:PS50089:20=[CH]> and <Feature:PS50089:39=[CH]> and <Feature:PS50089:42=[CH]>)
Zinc
Metal-binding
end case

Cross-references [?]

PROSITE PS00518; ZF_RING_1; 1;

Features [?]

From: PS50089
Key From To Description Tag Condition FTGroup
case <Feature:PS50089:1=[C]> and <Feature:PS50089:4=[C]> and <Feature:PS50089:18=[C]> and <Feature:PS50089:20=[H]> and <Feature:PS50089:23=[C]> and <Feature:PS50089:26=[C]> and <Feature:PS50089:39=[C]> and <Feature:PS50089:42=[C]>
ZN_FING from to /note="RING-type #"
else case <Feature:PS50089:1=[CH]> and <Feature:PS50089:4=[CH]> and <Feature:PS50089:18=[CH]> and <Feature:PS50089:20=[CH]> and <Feature:PS50089:23=[CH]> and <Feature:PS50089:26=[CH]> and <Feature:PS50089:39=[CH]> and <Feature:PS50089:42=[CH]>
ZN_FING from to /note="RING-type #; atypical"
else
ZN_FING from to /note="RING-type #; degenerate"
end case

Additional information [?]

Size range 10-70 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]