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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00190


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00190
General rule information [?]

Accession PRU00190
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 16)
Data class Domain;
Predictors PROSITE; PS50280; SET
Name SET
Function Lysine N-methyltransferase
Scope(s) Eukaryota
Example(s) P42124;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <Feature:PS50280:129=Y>
Protein name + RecName: EC=2.1.1.-;

Comments [?]

SIMILARITYBelongs to the class V-like SAM-binding methyltransferase superfamily.
end case

Keywords [?]

case <Feature:PS50280:129=Y>
Methyltransferase
S-adenosyl-L-methionine
Transferase
end case

Features [?]

From: PS50280
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="SET #"
case <AnyFeature:PS50868:5-12=C-x-C-x(4)-C>
BINDING 96 96 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#4"		 C 1
end case
BINDING 129 129 /ligand="S-adenosyl-L-methionine"
/ligand_id="ChEBI:CHEBI:59789"		 Y

Additional information [?]

Size range 116-469 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]