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annotation rule: PRU00204 |
Accession | PRU00204 |
Dates | 12-DEC-2003 (Created) 28-NOV-2019 (Last updated, Version 8) |
Data class | Domain |
Predictors | PROSITE; PS50104; TIR |
Name | TIR |
Function | The TIR domain has been defined as a scaffold that promotes assembly of signaling complexes via protein-protein interactions. However, the scaffolding function may be a a recent adaptation. The primordial function of the TIR domain is a self-association-dependent nicotinamide dinucleotide (NAD(+))-cleaving enzyme (NADase) activity that cleaves NAD(+) into nicotinamide (Nam) and ADP-ribose (ADPR), cyclic ADPR (cADPR) or variant cADPR (v-cADPR), with catalytic cleavage executed by a conserved glutamic acid. |
+ AltName: Full=Probable NAD(+) hydrolase; EC 3.2.2.6; |
Catalytic activity | RHEA:16301: H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide
EC 3.2.2.6 PhysiologicalDirection=left-to-right (RHEA:16302) |
Domain | The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. |
From: PS50104 | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | TIR # | |||||||||
ACT_SITE | 77 | 77 | act_site | E |
Size range | 125-180 amino acids |
Related rules | None |
Repeats | 1 |
Topology | Undefined |
Example | Q6SZW1 (SARM1_HUMAN) |
Scope | Eukaryota |
Archaea | [2] | |
Bacteria | [16] | |
Eukaryota | [190] | |
All | [ 208 ] |