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| annotation rule: PRU00204 |
General rule information
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| Accession | PRU00204 |
| Dates | 12-DEC-2003 (Created) 28-NOV-2019 (Last updated, Version 8) |
| Data class | Domain |
| Predictors | PROSITE; PS50104; TIR |
| Name | TIR |
| Function | The TIR domain has been defined as a scaffold that promotes assembly of signaling complexes via protein-protein interactions. However, the scaffolding function may be a a recent adaptation. The primordial function of the TIR domain is a self-association-dependent nicotinamide dinucleotide (NAD(+))-cleaving enzyme (NADase) activity that cleaves NAD(+) into nicotinamide (Nam) and ADP-ribose (ADPR), cyclic ADPR (cADPR) or variant cADPR (v-cADPR), with catalytic cleavage executed by a conserved glutamic acid. |
Propagated annotation
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Description
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case <FTTag:act_site>
| + AltName: Full=Probable NAD(+) hydrolase; EC 3.2.2.6; |
Comments
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| Catalytic activity | RHEA:16301: H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide
EC 3.2.2.6 PhysiologicalDirection=left-to-right (RHEA:16302) |
| Domain | The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. |
Keywords
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end case
Features
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| From: PS50104 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | TIR # | |||||||||
| ACT_SITE | 77 | 77 | act_site | E | ||||||||
case <FTTag:NAD_bind>
end case
case <FTTag:act_site>
end case
Additional information
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| Size range | 125-180 amino acids |
| Related rules | None |
| Repeats | 1 |
| Topology | Undefined |
| Example | Q6SZW1 (SARM1_HUMAN) |
| Scope | Eukaryota |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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