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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00238


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00238
General rule information [?]

Accession PRU00238
Dates 12-DEC-2003 (Created)
10-JAN-2024 (Last updated, Version 17)
Data class Domain;
Predictors PROSITE; PS01033; GLOBIN
Name Globin domain
Function Globins are heme-containing proteins involved in binding and/or transporting oxygen.
Scope(s) Eukaryota
Bacteria
Example(s) Q8WWM9;

Propagated annotation [?]

Comments [?]

case not <OC:Bacteria>
SIMILARITYBelongs to the globin family.
end case

Keywords [?]

Oxygen transport
end case
case <FTGroup:1> or <FTGroup:2>
Heme
Iron
Metal-binding
Transport
end case

Gene Ontology [?]

case <FTGroup:1> or <FTGroup:2>
GO:0006810; Biological process:transport
end case
case <FTGroup:1>
GO:0015671; Biological process:oxygen transport

Features [?]

From: PS01033
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Globin #"
case <Feature:PS01033:61-62=H-G>
BINDING 61 61 /ligand="O2"
/ligand_id="ChEBI:CHEBI:15379"		 H 1
BINDING 93 93 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="proximal binding residue"		 H 1
else
BINDING 61 61 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="distal binding residue"		 [HQ] 2
BINDING 93 93 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="proximal binding residue"		 H 2
end case

Additional information [?]

Size range 108-151 amino acids
Related rules None
Fusion None
Repeats 1-9
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]