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annotation rule: PRU00239

General rule information [?]

Accession PRU00239
Dates 12-DEC-2003 (Created)
16-DEC-2016 (Last updated, Version 8)
Data class Domain
Predictors PROSITE; PS50203; CALPAIN_CAT
Name Cysteine proteinase, calpain-type, catalytic domain
Function Calpains are a family of cytosolic cysteine proteinases

Propagated annotation [?]


Description [?]

case <FTGroup:1>
+ RecName: EC=3.4.22.-;
end case


Gene Ontology [?]

case <FTGroup:1>
GO:0008234; Molecular function: cysteine-type peptidase activity.
GO:0016787; Molecular function: hydrolase activity.
GO:0008233; Molecular function: peptidase activity.

Keywords [?]

end case


Features [?]

From: PS50203
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Calpain catalytic #        
ACT_SITE     61     61             C   1
ACT_SITE     222     222             H   1
ACT_SITE     243     243             N   1

Additional information [?]

Size range 291-344 amino acids
Related rules None
Repeats 1
Topology Cytoplasmic
Example Q9HC96 (CAN10_HUMAN)
Scope
Eukaryota
Bacteria

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]