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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00239


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00239
General rule information [?]

Accession PRU00239
Dates 12-DEC-2003 (Created)
21-NOV-2019 (Last updated, Version 10)
Data class Domain;
Predictors PROSITE; PS50203; CALPAIN_CAT
Name Cysteine proteinase, calpain-type, catalytic domain
Function Calpains are a family of cytosolic cysteine proteinases
Scope(s) Eukaryota
Bacteria
Example(s) Q9HC96;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=3.4.22.-;
end case

Keywords [?]

Hydrolase
Protease
Thiol protease
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0008234; Molecular function:cysteine-type peptidase activity
GO:0016787; Molecular function:hydrolase activity
GO:0008233; Molecular function:peptidase activity

Features [?]

From: PS50203
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Calpain catalytic #"
ACT_SITE 61 61 C 1
ACT_SITE 222 222 H 1
ACT_SITE 243 243 N 1

Additional information [?]

Size range 291-344 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]