ProRule PRU00239
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00239 |
| Accession | PRU00239 |
| Dates | 12-DEC-2003 (Created)
21-NOV-2019 (Last updated, Version 9) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50203; CALPAIN_CAT |
Name | Cysteine proteinase, calpain-type, catalytic domain |
| Function | Calpains are a family of cytosolic cysteine proteinases |
| Scope(s) |
Eukaryota Bacteria |
| Example(s) | Q9HC96 (CAN10_HUMAN); |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> | |
| Protein name | + RecName: EC=3.4.22.-; |
| end case | |
Keywords
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| Hydrolase | |
| Protease | |
| Thiol protease | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0008234; Molecular function:cysteine-type peptidase activity | |
| GO:0016787; Molecular function:hydrolase activity | |
| GO:0008233; Molecular function:peptidase activity | |
Features
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| From: PS50203 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Calpain catalytic #" | |||||||||
| ACT_SITE | 61 | 61 | C | 1 | ||||||||
| ACT_SITE | 222 | 222 | H | 1 | ||||||||
| ACT_SITE | 243 | 243 | N | 1 | ||||||||
Additional information
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| Size range | 291-344 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [1] Eukaryota [78] All [ 79 ]
- Retrieve set of proteins with 3D structure for this domain