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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00242


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00242
General rule information [?]

Accession PRU00242
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 15)
Data class Domain;
Predictors PROSITE; PS50939; CYTOCHROME_B561
Name Cytochrome b561 domain
Function Cytochromes b561 are di-heme transmembrane electron transport proteins.
Scope(s) Eukaryota
Example(s) P49447;

Propagated annotation [?]

Keywords [?]

Electron transport
Membrane
Transmembrane
Transport
case <FTGroup:1>
Heme
Iron
Metal-binding
end case

Gene Ontology [?]

GO:0016020; Cellular component:membrane
GO:0006810; Biological process:transport
case <FTGroup:1>
GO:0005506; Molecular function:iron ion binding
GO:0046872; Molecular function:metal ion binding
end case

Features [?]

From: PS50939
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Cytochrome b561 #"
BINDING 37 37 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/ligand_label="1"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H 1
BINDING 73 73 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/ligand_label="2"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H 1
BINDING 95 95 /ligand="Fe(3+)"
/ligand_id="ChEBI:CHEBI:29034"
/ligand_note="substrate"		 H 1
BINDING 107 107 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/ligand_label="1"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H 1
BINDING 146 146 /ligand="heme b"
/ligand_id="ChEBI:CHEBI:60344"
/ligand_label="2"
/ligand_part="Fe"
/ligand_part_id="ChEBI:CHEBI:18248"
/note="axial binding residue"		 H 1

Additional information [?]

Size range 198-214 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]