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General rule information [?]

Accession PRU00276
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 13)
Data class Domain
Predictors PROSITE; PS50215; ADAM_MEPRO
Name ADAM type metalloprotease domain
Function Belongs to peptidase family M12B

Propagated annotation [?]

Keywords [?]

case <FTGroup:1>
end case

case <FTTag:disulf>
end case

Features [?]

From: PS50215
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase M12B #        
BINDING     137     137       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
ACT_SITE     138     138             E  
BINDING     141     141       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
BINDING     147     147       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic     H   1
DISULFID     112     192           disulf   C-x*-C  
DISULFID     152     176           disulf   C-x*-C  
DISULFID     154     159           disulf   C-x*-C  

Additional information [?]

Size range 150-252 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P83255 (VM1F_MACLB)


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]