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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00276


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00276
General rule information [?]

Accession PRU00276
Dates 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 14)
Data class Domain;
Predictors PROSITE; PS50215; ADAM_MEPRO
Name ADAM type metalloprotease domain
Function Belongs to peptidase family M12B
Scope(s) Eukaryota
Example(s) P83255;

Propagated annotation [?]

Keywords [?]

case <FTGroup:1>
Metal-binding
Zinc
end case
case <FTTag:disulf>
Disulfide bond
end case

Features [?]

From: PS50215
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase M12B #"
BINDING 137 137 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 H 1
ACT_SITE 138 138 E
BINDING 141 141 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 H 1
BINDING 147 147 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_note="catalytic"		 H 1
DISULFID 112 192 disulf C-x*-C
DISULFID 152 176 disulf C-x*-C
DISULFID 154 159 disulf C-x*-C

Additional information [?]

Size range 150-252 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]