ProRule PRU00276
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00276 |
| Accession | PRU00276 |
| Dates | 12-DEC-2003 (Created)
19-NOV-2022 (Last updated, Version 13) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50215; ADAM_MEPRO |
Name | ADAM type metalloprotease domain |
| Function | Belongs to peptidase family M12B |
| Scope(s) |
Eukaryota |
| Example(s) | P83255 (VM1F_MACLB); |
Propagated annotation
[?]
Keywords
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| case <FTGroup:1> | |
| Metal-binding | |
| Zinc | |
| end case | |
| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Features
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| From: PS50215 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Peptidase M12B #" | |||||||||
| BINDING | 137 | 137 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| ACT_SITE | 138 | 138 | E | |||||||||
| BINDING | 141 | 141 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| BINDING | 147 | 147 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" /ligand_note="catalytic" |
H | 1 | |||||||
| DISULFID | 112 | 192 | disulf | C-x*-C | ||||||||
| DISULFID | 152 | 176 | disulf | C-x*-C | ||||||||
| DISULFID | 154 | 159 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 150-252 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [335] All [ 335 ]
- Retrieve set of proteins with 3D structure for this domain