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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00277


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00277
General rule information [?]

Accession PRU00277
Dates 12-DEC-2003 (Created)
21-NOV-2019 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS50059; FKBP_PPIASE
Name PPIase FKBP-type domain
Function Peptidyl-prolyl cis-trans isomerase activity (EC 5.2.1.8)
Scope(s) Eukaryota
Bacteria
Archaea
Example(s) Q02790;

Propagated annotation [?]

Identifier, protein and gene names [?]

Protein name + RecName: EC=5.2.1.8;

Comments [?]

CATALYTIC ACTIVITY Reaction=[protein]-peptidylproline (omega=180) = [protein]- peptidylproline (omega=0); Xref=Rhea:RHEA:16237, Rhea:RHEA- COMP:10747, Rhea:RHEA-COMP:10748, ChEBI:CHEBI:83833, ChEBI:CHEBI:83834; EC=5.2.1.8;

Keywords [?]

Isomerase
Rotamase

Gene Ontology [?]

GO:0016853; Molecular function:isomerase activity

Features [?]

From: PS50059
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PPIase FKBP-type #"

Additional information [?]

Size range 72-130 amino acids
Related rules None
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]