ProRule PRU00304
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00304 |
| Accession | PRU00304 |
| Dates | 19-DEC-2003 (Created)
21-NOV-2019 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50211; DENN |
Name | DENN domain |
| Function | The tripartite DENN domain is composed of three distinct modules which are always associated due to functional and/or structural constraints: upstream DENN or uDENN, the better conserved central or core or cDENN, and downstream or dDENN regions. The function of DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | O02626 (MADD_CAEEL); |
Propagated annotation
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Features
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| From: PS50211 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | 162 | /note="uDENN #" | |||||||||
| DOMAIN | 185 | 321 | /note="cDENN #" | |||||||||
| DOMAIN | 323 | to | /note="dDENN #" | |||||||||
Additional information
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| Size range | 180-230 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [71] All [ 71 ]
- Retrieve set of proteins with 3D structure for this domain