ProRule PRU00304

General rule information [?]

Accession PRU00304
Dates 19-DEC-2003 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS50211; DENN
Name DENN domain
Function The tripartite DENN domain is composed of three distinct modules which are always associated due to functional and/or structural constraints: upstream DENN or uDENN, the better conserved central or core or cDENN, and downstream or dDENN regions. The function of DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.
Scope(s) Eukaryota
Example(s) O02626 (MADD_CAEEL);

Propagated annotation [?]

Features [?]

From: PS50211
Key From To Description Tag Condition FTGroup
DOMAIN from 162 /note="uDENN #"
DOMAIN 185 321 /note="cDENN #"
DOMAIN 323 to /note="dDENN #"

Additional information [?]

Size range 180-230 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

View rule in raw text format (no links)

UniProtKB rule member sequences [?]