ProRule PRU00312
General rule information
[?]
| Accession | PRU00312 |
| Dates | 12-JAN-2004 (Created)
27-JUN-2022 (Last updated, Version 13) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50953; KID |
Name | KID domain |
| Function | Ser-133 phosphorylation of CREB within the KID domain promotes target gene activation via complex formation with the KIX domain of the CBP and P300 coactivators, whereas concurrent phosphorylation of the CREB KID domain at Ser-142 inhibits transcriptional induction. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | P16220 (CREB1_HUMAN); |
Propagated annotation
[?]
Comments
[?]
| SUBCELLULAR LOCATION | Nucleus. |
Keywords
[?]
| DNA-binding | |
| Nucleus | |
| case <Feature:PS50953:33=S> or <Feature:PS50953:42=S> | |
| Phosphoprotein | |
| end case | |
| Transcription | |
| Transcription regulation | |
Gene Ontology
[?]
| GO:0003677; Molecular function:DNA binding |
| GO:0005634; Cellular component:nucleus |
| GO:0006355; Biological process:regulation of DNA-templated transcription |
| GO:0006351; Biological process:DNA-templated transcription |
Features
[?]
| From: PS50953 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="KID #" | |||||||||
| MOD_RES | 33 | 33 | /note="Phosphoserine" | S | ||||||||
| MOD_RES | 42 | 42 | /note="Phosphoserine" | S | ||||||||
Additional information
[?]
| Size range | 55-65 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
[?]
- UniProtKB/Swiss-Prot sets
Eukaryota [16] All [ 16 ]
- Retrieve set of proteins with 3D structure for this domain