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annotation rule: PRU00312

General rule information [?]

Accession PRU00312
Dates 12-JAN-2004 (Created)
21-NOV-2019 (Last updated, Version 12)
Data class Domain
Predictors PROSITE; PS50953; KID
Name KID domain
Function Ser-133 phosphorylation of CREB within the KID domain promotes target gene activation via complex formation with the KIX domain of the CBP and P300 coactivators, whereas concurrent phosphorylation of the CREB KID domain at Ser-142 inhibits transcriptional induction.

Propagated annotation [?]

Comments [?]

Subcellular location Nucleus.

Gene Ontology [?]

GO:0003677; Molecular function: DNA binding.
GO:0005634; Cellular component: nucleus.
GO:0006355; Biological process: regulation of transcription, DNA-templated.
GO:0006351; Biological process: transcription, DNA-templated.

Keywords [?]

case <Feature:PS50953:33=S> or <Feature:PS50953:42=S>
end case

Features [?]

From: PS50953
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       KID #        
MOD_RES     33     33       Phosphoserine     S  
MOD_RES     42     42       Phosphoserine     S  

Additional information [?]

Size range 55-65 amino acids
Related rules None
Repeats 1
Topology Cytoplasmic
Example P16220 (CREB1_HUMAN)
Eukaryota; Metazoa


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]