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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00315


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00315
General rule information [?]

Accession PRU00315
Dates 22-JAN-2004 (Created)
21-NOV-2019 (Last updated, Version 20)
Data class Domain;
Predictors PROSITE; PS50948; PAN
Name PAN/Apple domain
Function The PAN/Apple domain has been shown to bind directly to kininogen, factor XIIa, platelets,factor IX and heparin.
Scope(s) Eukaryota
Metazoa
Example(s) P03951; P14210;

Propagated annotation [?]

Keywords [?]

case <FTTag:disulf>
Disulfide bond
end case

Cross-references [?]

PROSITE PS00495; APPLE; 1;

Features [?]

From: PS50948
Key From To Description Tag Condition FTGroup
case <AnyFeature:PS50948:1={C}> or <AnyFeature:PS50948:78={C}>
DOMAIN from to /note="PAN #"
else
DOMAIN from to /note="Apple #"
end case
DISULFID 1 78 disulf C-x*-C
DISULFID 30 52 disulf C-x*-C
DISULFID 34 40 disulf C-x*-C

Additional information [?]

Size range 72-95 amino acids
Related rules None
Fusion None
Repeats 4
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]