ProRule PRU00315
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00315 |
| Accession | PRU00315 |
| Dates | 22-JAN-2004 (Created)
21-NOV-2019 (Last updated, Version 19) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50948; PAN |
Name | PAN/Apple domain |
| Function | The PAN/Apple domain has been shown to bind directly to kininogen, factor XIIa, platelets,factor IX and heparin. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | P03951 (FA11_HUMAN); P14210 (HGF_HUMAN); |
Propagated annotation
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Keywords
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| case <FTTag:disulf> | |
| Disulfide bond | |
| end case | |
Cross-references
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| PROSITE | PS00495; APPLE; 1; |
Features
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| From: PS50948 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| case <AnyFeature:PS50948:1={C}> or <AnyFeature:PS50948:78={C}> | ||||||||||||
| DOMAIN | from | to | /note="PAN #" | |||||||||
| else | ||||||||||||
| DOMAIN | from | to | /note="Apple #" | |||||||||
| end case | ||||||||||||
| DISULFID | 1 | 78 | disulf | C-x*-C | ||||||||
| DISULFID | 30 | 52 | disulf | C-x*-C | ||||||||
| DISULFID | 34 | 40 | disulf | C-x*-C | ||||||||
Additional information
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| Size range | 72-95 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 4 |
| Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [99] Viruses [2] All [ 101 ]
- Retrieve set of proteins with 3D structure for this domain