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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00331


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00331
General rule information [?]

Accession PRU00331
Dates 29-MAR-2004 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS50957; JOSEPHIN
Name Josephin domain
Function The Josephin domain is believed to be a mainly alpha helical cysteine-protease domain predicted to be active against ubiquitin chains or related substrates.
Scope(s) Eukaryota
Example(s) Q15040;

Propagated annotation [?]

Keywords [?]

case <FTGroup:1>
Hydrolase
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0016787; Molecular function:hydrolase activity
end case

Features [?]

From: PS50957
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Josephin #"
ACT_SITE 14 14 C 1
ACT_SITE 117 117 H 1
ACT_SITE 132 132 [DN] 1

Additional information [?]

Size range 165-195 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]