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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00333


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00333
General rule information [?]

Accession PRU00333
Dates 02-APR-2004 (Created)
19-NOV-2022 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS50970; HCY
Name Homocysteine-binding domain
Function The homocysteine- (Hcy-)binding domain utilizes a Zn(Cys)3 cluster to bind and activate Hcy.
Scope(s) Eukaryota
Bacteria
Example(s) Q9SDL7;

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
end case

Keywords [?]

case <FTGroup:1>
Zinc
Metal-binding
Transferase
Methyltransferase
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0016740; Molecular function:transferase activity
GO:0008168; Molecular function:methyltransferase activity
end case

Features [?]

From: PS50970
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Hcy-binding #"
BINDING 215 215 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 281 281 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 282 282 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1

Additional information [?]

Size range 295-330 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]