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ProRule PRU00333


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PURL: https://purl.expasy.org/prosite/rule/PRU00333
General rule information [?]

Accession PRU00333
Dates 02-APR-2004 (Created)
19-NOV-2022 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS50970; HCY
Name Homocysteine-binding domain
Function The homocysteine- (Hcy-)binding domain utilizes a Zn(Cys)3 cluster to bind and activate Hcy.
Scope(s) Eukaryota
Bacteria
Example(s) Q9SDL7 (HMT1_ARATH);

Propagated annotation [?]

Comments [?]

case <FTGroup:1>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
end case

Keywords [?]

case <FTGroup:1>
Zinc
Metal-binding
Transferase
Methyltransferase
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0016740; Molecular function:transferase activity
GO:0008168; Molecular function:methyltransferase activity
end case

Features [?]

From: PS50970
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Hcy-binding #"
BINDING 215 215 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 281 281 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1
BINDING 282 282 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"		 C 1

Additional information [?]

Size range 295-330 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic

Copyright

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UniProtKB rule member sequences [?]