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annotation rule: PRU00333

General rule information [?]

Accession PRU00333
Dates 2-APR-2004 (Created)
19-NOV-2022 (Last updated, Version 12)
Data class Domain
Predictors PROSITE; PS50970; HCY
Name Homocysteine-binding domain
Function The homocysteine- (Hcy-)binding domain utilizes a Zn(Cys)3 cluster to bind and activate Hcy.

Propagated annotation [?]


Comments [?]

case <FTGroup:1>
Cofactor Zn(2+)
end case


Gene Ontology [?]

case <FTGroup:1>
GO:0016740; Molecular function: transferase activity.
GO:0008168; Molecular function: methyltransferase activity.

Keywords [?]

Zinc
Metal-binding
Transferase
Methyltransferase
end case


Features [?]

From: PS50970
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Hcy-binding #        
BINDING     215     215       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     281     281       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1
BINDING     282     282       /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105     C   1

Additional information [?]

Size range 295-330 amino acids
Related rules None
Repeats 1
Topology Cytoplasmic
Example Q9SDL7 (HMT1_ARATH)
Scope
Eukaryota
Bacteria

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]