ProRule PRU00333
General rule information
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| Accession | PRU00333 |
| Dates | 2-APR-2004 (Created)
19-NOV-2022 (Last updated, Version 12) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50970; HCY |
Name | Homocysteine-binding domain |
| Function | The homocysteine- (Hcy-)binding domain utilizes a Zn(Cys)3 cluster to bind and activate Hcy. |
| Scope(s) |
Eukaryota Bacteria |
| Example(s) | Q9SDL7 (HMT1_ARATH); |
Propagated annotation
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Comments
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| case <FTGroup:1> | |
| COFACTOR | Name=Zn(2+); Xref=ChEBI:CHEBI:29105; |
| end case | |
Keywords
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| case <FTGroup:1> | |
| Zinc | |
| Metal-binding | |
| Transferase | |
| Methyltransferase | |
| end case | |
Gene Ontology
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| case <FTGroup:1> | |
| GO:0016740; Molecular function:transferase activity | |
| GO:0008168; Molecular function:methyltransferase activity | |
| end case | |
Features
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| From: PS50970 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Hcy-binding #" | |||||||||
| BINDING | 215 | 215 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 281 | 281 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
| BINDING | 282 | 282 | /ligand="Zn(2+)" /ligand_id="ChEBI:CHEBI:29105" |
C | 1 | |||||||
Additional information
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| Size range | 295-330 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Bacteria [16] Eukaryota [34] All [ 50 ]
- Retrieve set of proteins with 3D structure for this domain