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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00380


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00380
General rule information [?]

Accession PRU00380
Dates 06-JAN-2005 (Created)
27-JUN-2022 (Last updated, Version 11)
Data class Domain;
Predictors PROSITE; PS51054; ORANGE
Name Orange domain
Function The Orange domain is a ~35 residue domain of unknown function, present in eukaryotic DNA-binding transcription repressors which regulate cell differentiation, embryonic patterning and other biological processes in both vertebrates and invertebrates.
Scope(s) Eukaryota
Metazoa
Example(s) O14503;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.

Keywords [?]

Nucleus
Transcription
Transcription regulation

Gene Ontology [?]

GO:0005634; Cellular component:nucleus
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Features [?]

From: PS51054
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Orange #"

Additional information [?]

Size range 20-45 amino acids
Related rules None
Fusion None
Repeats 1
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]