We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00389
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00389
General rule information
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| Accession | PRU00389 |
| Dates | 21-JAN-2005 (Created)
21-NOV-2019 (Last updated, Version 8) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51064; IRS_PTB |
Name | IRS-type PTB domain |
| Function | IRS-type PTB domain has an average length of about 100 amino acids. It binds to the insulin receptor through the Asn-Pro-Xaa-Tyr(P) motif found in many tyrosine-phosphorylated proteins. |
| Scope(s) |
Eukaryota |
| Example(s) | Q99704; P35568; |
Propagated annotation
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Cross-references
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| PROSITE | PS51064; IRS_PTB; 1; |
Features
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| From: PS51064 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="IRS-type PTB #" | |||||||||
Additional information
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| Size range | 105 amino acids |
| Related rules |
none |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [44] All [ 44 ]
- Retrieve set of proteins with 3D structure for this domain