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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00391


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00391
General rule information [?]

Accession PRU00391
Dates 04-FEB-2005 (Created)
21-NOV-2019 (Last updated, Version 13)
Data class Domain;
Predictors PROSITE; PS51066; ZF_FPG_2
Name Zinc finger FPG-type
Function Zinc finger specific to Formamidopyrimidine-DNA glycosylase and Endonuclease VIII. It binds DNA.
Scope(s) Eukaryota
Bacteria
Archaea
Example(s) P64159;

Propagated annotation [?]

Comments [?]

case <Feature:PS51066:10=[C]> and <Feature:PS51066:13=[C]> and <Feature:PS51066:30=[C]> and <Feature:PS51066:33=[C]>
COFACTOR Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
end case

Keywords [?]

Zinc-finger
case <Feature:PS51066:10=[CH]> and <Feature:PS51066:13=[CH]> and <Feature:PS51066:30=[CH]> and <Feature:PS51066:33=[CH]>
Zinc
Metal-binding
end case

Cross-references [?]

PROSITE PS01242; ZF_FPG_1; 1;

Features [?]

From: PS51066
Key From To Description Tag Condition FTGroup
case <Feature:PS51066:10=[C]> and <Feature:PS51066:13=[C]> and <Feature:PS51066:30=[C]> and <Feature:PS51066:33=[C]>
ZN_FING from to /note="FPG-type #"
else case <Feature:PS51066:10=[CH]> and <Feature:PS51066:13=[CH]> and <Feature:PS51066:30=[CH]> and <Feature:PS51066:33=[CH]>
ZN_FING from to /note="FPG-type #; atypical"
else
ZN_FING from to /note="FPG-type #; degenerate"
ACT_SITE 25 25 /note="Proton donor (in delta-elimination)" R
end case

Additional information [?]

Size range 25-50 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]