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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00397


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00397
General rule information [?]

Accession PRU00397
Dates 11-FEB-2005 (Created)
03-JUN-2021 (Last updated, Version 9)
Data class Domain;
Predictors PROSITE; PS51059; PARP_CATALYTIC
Name PARP catalytic domain
Function Poly(ADP-ribose) polymerase (PARP) transfers the ADP-ribose moiety from its substrate, nicotinamide adenine dinucleotide (NAD), to carboxylate groups of aspartic and glutamic residues.
Scope(s) Eukaryota
Example(s) P35875;

Propagated annotation [?]

Keywords [?]

Glycosyltransferase
NAD
Transferase

Gene Ontology [?]

GO:0016740; Molecular function:transferase activity
GO:0016757; Molecular function:glycosyltransferase activity

Features [?]

From: PS51059
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PARP catalytic #"

Additional information [?]

Size range 185-235 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]