We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00404
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00404
General rule information
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| Accession | PRU00404 |
| Dates | 15-FEB-2005 (Created)
21-NOV-2019 (Last updated, Version 7) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51072; MHD |
Name | Mu homology domain (MHD) |
| Function | The MHD domain is found in endocytotic proteins involved in clathrin-mediated endocytosis and has been shown to bind to the C2B domain of members of the synaptotagmin family. |
| Scope(s) |
Eukaryota |
| Example(s) | P38153; |
Propagated annotation
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Keywords
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Gene Ontology
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| GO:0006886; Biological process:intracellular protein transport |
| GO:0030131; Cellular component:clathrin adaptor complex |
Features
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| From: PS51072 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="MHD #" | |||||||||
Additional information
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| Size range | 240-345 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [95] All [ 95 ]
- Retrieve set of proteins with 3D structure for this domain