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annotation rule: PRU00409

General rule information [?]

Accession PRU00409
Dates 3-MAR-2005 (Created)
21-NOV-2019 (Last updated, Version 22)
Data class Domain
Predictors PROSITE; PS50975; ATP_GRASP
Name ATP-grasp domain
Function The ATP-grasp superfamily currently includes 17 groups of enzymes, catalyzing ATP-dependent ligation of a carboxylate containing molecule to an amino or thiol group-containing molecule.

Propagated annotation [?]

Comments [?]

case <FTGroup:1> or <FTGroup:2>
Cofactor Mg(2+)
Note: Binds #(magnesium or manganese,ion) per subunit.
end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0000166; Molecular function: nucleotide binding.
case <FTGroup:1> or <FTGroup:2>
GO:0000287; Molecular function: magnesium ion binding.
GO:0030145; Molecular function: manganese ion binding.
end case

Keywords [?]

case <FTGroup:1> or <FTGroup:2>
end case

Features [?]

From: PS50975
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       ATP-grasp #        
case not <Triggered>
NP_BIND     27     84       ATP        
end case

METAL     152     152       Magnesium or manganese #1     [QDE]   1
METAL     165     165       Magnesium or manganese #1     E   1
METAL     165     165       Magnesium or manganese #2     E   2
METAL     167     167       Magnesium or manganese #2     N   2

Additional information [?]

case not <FTGroup:1> or not <FTGroup:2>
Warning one magnesium or manganese binding site was not detected!
end case

Size range 140-255 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q75D66 (CARB_ASHGO)


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UniProtKB rule member sequences [?]