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General rule information [?]

Accession PRU00409
Dates 3-MAR-2005 (Created)
19-NOV-2022 (Last updated, Version 28)
Data class Domain
Predictors PROSITE; PS50975; ATP_GRASP
Name ATP-grasp domain
Function The ATP-grasp superfamily currently includes 17 groups of enzymes, catalyzing ATP-dependent ligation of a carboxylate containing molecule to an amino or thiol group-containing molecule.

Propagated annotation [?]

Comments [?]

case <FTGroup:1> or <FTGroup:2>
Cofactor Mg(2+)
Note: Binds #(Mg(2+)~Mn(2+),ion) per subunit.
end case

Gene Ontology [?]

GO:0005524; Molecular function: ATP binding.
GO:0000166; Molecular function: nucleotide binding.
case <FTGroup:1> or <FTGroup:2>
GO:0000287; Molecular function: magnesium ion binding.
GO:0030145; Molecular function: manganese ion binding.
end case

Keywords [?]

case <FTGroup:1> or <FTGroup:2>
end case

Features [?]

From: PS50975
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       ATP-grasp #        
case not <Triggered>
BINDING     27     84       /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616        
end case

BINDING     152     152       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#1     [QDE]   1
BINDING     152     152       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1     [QDE]   1
BINDING     165     165       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#1     E   1
BINDING     165     165       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1     E   1
BINDING     165     165       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#2     E   2
BINDING     165     165       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2     E   2
BINDING     167     167       /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#2     N   2
BINDING     167     167       /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2     N   2

Additional information [?]

case not <FTGroup:1> or not <FTGroup:2>
Warning one magnesium or manganese binding site was not detected!
end case

Size range 140-255 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q75D66 (CARB_ASHGO)


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]