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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00409


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00409
General rule information [?]

Accession PRU00409
Dates 03-MAR-2005 (Created)
19-NOV-2022 (Last updated, Version 29)
Data class Domain;
Predictors PROSITE; PS50975; ATP_GRASP
Name ATP-grasp domain
Function The ATP-grasp superfamily currently includes 17 groups of enzymes, catalyzing ATP-dependent ligation of a carboxylate containing molecule to an amino or thiol group-containing molecule.
Scope(s) Eukaryota
Bacteria
Archaea
Example(s) Q75D66;

Propagated annotation [?]

Comments [?]

case <FTGroup:1> or <FTGroup:2>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds #(Mg(2+)~Mn(2+),ion) per subunit.;
end case

Keywords [?]

ATP-binding
Nucleotide-binding
case <FTGroup:1> or <FTGroup:2>
Magnesium
Manganese
Metal-binding
end case

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0000166; Molecular function:nucleotide binding
case <FTGroup:1> or <FTGroup:2>
GO:0000287; Molecular function:magnesium ion binding
GO:0030145; Molecular function:manganese ion binding
end case

Features [?]

From: PS50975
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ATP-grasp #"
case not <Triggered>
BINDING 27 84 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
end case
BINDING 152 152 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="#1"		 [QDE] 1
BINDING 152 152 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#1"		 [QDE] 1
BINDING 165 165 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="#1"		 E 1
BINDING 165 165 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#1"		 E 1
BINDING 165 165 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="#2"		 E 2
BINDING 165 165 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#2"		 E 2
BINDING 167 167 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="#2"		 N 2
BINDING 167 167 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#2"		 N 2

Additional information [?]

Size range 140-255 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]