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ProRule PRU00409


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PURL: https://purl.expasy.org/prosite/rule/PRU00409
General rule information [?]

Accession PRU00409
Dates 03-MAR-2005 (Created)
19-NOV-2022 (Last updated, Version )
Data class Domain;
Predictors PROSITE; PS50975; ATP_GRASP
Name ATP-grasp domain
Function The ATP-grasp superfamily currently includes 17 groups of enzymes, catalyzing ATP-dependent ligation of a carboxylate containing molecule to an amino or thiol group-containing molecule.
Scope(s) Eukaryota
Bacteria
Archaea
Example(s) Q75D66;

Propagated annotation [?]

Comments [?]

case <FTGroup:1> or <FTGroup:2>
COFACTOR Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds #(Mg(2+)~Mn(2+),ion) per subunit.;
end case

Keywords [?]

ATP-binding
Nucleotide-binding
case <FTGroup:1> or <FTGroup:2>
Magnesium
Manganese
Metal-binding
end case

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0000166; Molecular function:nucleotide binding
case <FTGroup:1> or <FTGroup:2>
GO:0000287; Molecular function:magnesium ion binding
GO:0030145; Molecular function:manganese ion binding
end case

Features [?]

From: PS50975
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ATP-grasp #"
case not <Triggered>
BINDING 27 84 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
end case
BINDING 152 152 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="#1"		 [QDE] 1
BINDING 152 152 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#1"		 [QDE] 1
BINDING 165 165 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="#1"		 E 1
BINDING 165 165 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#1"		 E 1
BINDING 165 165 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="#2"		 E 2
BINDING 165 165 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#2"		 E 2
BINDING 167 167 /ligand="Mg(2+)"
/ligand_id="ChEBI:CHEBI:18420"
/ligand_label="#2"		 N 2
BINDING 167 167 /ligand="Mn(2+)"
/ligand_id="ChEBI:CHEBI:29035"
/ligand_label="#2"		 N 2

Additional information [?]

Size range 140-255 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]