ProRule PRU00409
General rule information
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| Accession | PRU00409 |
| Dates | 3-MAR-2005 (Created)
19-NOV-2022 (Last updated, Version 28) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50975; ATP_GRASP |
Name | ATP-grasp domain |
| Function | The ATP-grasp superfamily currently includes 17 groups of enzymes, catalyzing ATP-dependent ligation of a carboxylate containing molecule to an amino or thiol group-containing molecule. |
| Scope(s) |
Eukaryota Bacteria Archaea |
| Example(s) | Q75D66 (CARB_EREGS); |
Propagated annotation
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Comments
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| case <FTGroup:1> or <FTGroup:2> | |
| COFACTOR | Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Note=Binds #(Mg(2+)~Mn(2+),ion) per subunit.; |
| end case | |
Keywords
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| ATP-binding | |
| Nucleotide-binding | |
| case <FTGroup:1> or <FTGroup:2> | |
| Magnesium | |
| Manganese | |
| Metal-binding | |
| end case | |
Gene Ontology
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| GO:0005524; Molecular function:ATP binding | |
| GO:0000166; Molecular function:nucleotide binding | |
| case <FTGroup:1> or <FTGroup:2> | |
| GO:0000287; Molecular function:magnesium ion binding | |
| GO:0030145; Molecular function:manganese ion binding | |
| end case | |
Features
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| From: PS50975 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="ATP-grasp #" | |||||||||
| case not <Triggered> | ||||||||||||
| BINDING | 27 | 84 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
|||||||||
| end case | ||||||||||||
| BINDING | 152 | 152 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#1" |
[QDE] | 1 | |||||||
| BINDING | 152 | 152 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1" |
[QDE] | 1 | |||||||
| BINDING | 165 | 165 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#1" |
E | 1 | |||||||
| BINDING | 165 | 165 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#1" |
E | 1 | |||||||
| BINDING | 165 | 165 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#2" |
E | 2 | |||||||
| BINDING | 165 | 165 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2" |
E | 2 | |||||||
| BINDING | 167 | 167 | /ligand="Mg(2+)" /ligand_id="ChEBI:CHEBI:18420" /ligand_label="#2" |
N | 2 | |||||||
| BINDING | 167 | 167 | /ligand="Mn(2+)" /ligand_id="ChEBI:CHEBI:29035" /ligand_label="#2" |
N | 2 | |||||||
Additional information
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| Size range | 140-255 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [155] Bacteria [1902] Eukaryota [165] All [ 2222 ]
- Retrieve set of proteins with 3D structure for this domain