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annotation rule: PRU00415

General rule information [?]

Accession PRU00415
Dates 7-APR-2005 (Created)
12-MAR-2018 (Last updated, Version 7)
Data class Domain
Predictors PROSITE; PS50015; SAP_B
Name Saposin B-type domain
Function The saposin B-type domain is a ~80 amino acid domain present in saposins and related proteins that interact with lipids. In plant aspartic proteinases the two subdomains that are connected by disulfide bridges occur in inversed order, these "swapped" halves are called a "swaposin" domain.

Propagated annotation [?]


Keywords [?]

case <FT:5>
end case

case <FTTag:disulf>
end case


Features [?]

From: PS50015
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     entry     exit       Saposin B-type #        
DISULFID     5     79           disulf   C-x*-C   1
DISULFID     8     73           disulf   C-x*-C   2
DISULFID     36     48           disulf   C-x*-C   3
CARBOHYD     22     22       N-linked (GlcNAc...) asparagine     N  

Additional information [?]

case not <FTGroup:1> and not <FTGroup:2> and not <FTGroup:3>
Warning In plant aspartic proteinases two half SAP_B subdomains occur in inversed order. Correct the boundaries and check the three disulfide bonds in these "swaposins".
end case

Size range 35-160 amino acids
Related rules None
Repeats 1-8
Topology Undefined
Example P07602 (SAP_HUMAN)
Scope
Eukaryota

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



UniProtKB rule member sequences [?]