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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00422


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00422
General rule information [?]

Accession PRU00422
Dates 06-APR-2005 (Created)
21-NOV-2019 (Last updated, Version 18)
Data class Domain;
Predictors PROSITE; PS51099; PTS_EIIB_TYPE_2
Name PTS EIIB type-2 domain
Function Phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system.
Scope(s) Bacteria
Archaea
Example(s) P20966;

Propagated annotation [?]

Identifier, protein and gene names [?]

case (<OC:Bacteria> or <OC:Archaea>) and <Feature:PS51099:8=C>
Protein name + RecName: EC=2.7.1.-;

Comments [?]

DOMAINThe PTS EIIB type-2 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain.
end case

Keywords [?]

Phosphoprotein
Phosphotransferase system
Transferase
end case

Gene Ontology [?]

case (<OCellular component:Bacteria> or <OC:Archaea>) and <Feature:PS51099:8=C>
GO:0016740; Molecular function:transferase activity

Features [?]

From: PS51099
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PTS EIIB type-2 #"
MOD_RES 8 8 /note="Phosphocysteine; by EIIA" C

Additional information [?]

Size range 98 amino acids
Related rules none
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]