annotation rule: PRU00422

General rule information [?]

Accession PRU00422
Dates 6-APR-2005 (Created)
16-DEC-2016 (Last updated, Version 16)
Data class Domain
Predictors PROSITE; PS51099; PTS_EIIB_TYPE_2
Name PTS EIIB type-2 domain
Function Phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system.

Propagated annotation [?]

Description [?]

case (<OC:Bacteria> or <OC:Archaea>) and <Feature:PS51099:8=C>
+ RecName: EC=2.7.1.-;

Comments [?]

Domain The PTS EIIB type-2 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain.
end case

Gene Ontology [?]

case (<OC:Bacteria> or <OC:Archaea>) and <Feature:PS51099:8=C>
GO:0016740; Molecular function: transferase activity.

Keywords [?]

end case

Features [?]

From: PS51099
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       PTS EIIB type-2 #        
MOD_RES     8     8       Phosphocysteine; by EIIA     C  

Additional information [?]

Warning This domain can be found in other kind of proteins, mainly transcriptional regulators, in these cases it may serve as a regulatory function, through its phosphorylation activity, or as a simple phosphoryl. Check DE, KW, CC, FT DOMAIN AND CC CATALYTIC ACTIVITY.
Size range 98 amino acids
Related rules none
Repeats 1-2
Topology Undefined
Example P20966 (PTFBC_ECOLI)
Scope Bacteria


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UniProtKB rule member sequences [?]