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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00427


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00427
General rule information [?]

Accession PRU00427
Dates 06-APR-2005 (Created)
21-NOV-2019 (Last updated, Version 23)
Data class Domain;
Predictors PROSITE; PS51104; PTS_EIIC_TYPE_2
Name PTS EIIC type-2 domain
Function Phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system.
Scope(s) Bacteria
Archaea
Example(s) P42956;

Propagated annotation [?]

Comments [?]

case <OC:Bacteria> or <OC:Archaea>
DOMAINThe EIIC type-2 domain forms the PTS system translocation channel and contains the specific substrate-binding site.
end case
case <OC:Bacteria> and defined <Property:Membrane> and <Property:Membrane=2>
SUBCELLULAR LOCATIONCell inner membrane; Multi-pass membrane protein.
else case <OC:Bacteria> and defined <Property:Membrane> and <Property:Membrane=1>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else case <OC:Archaea> and defined <Property:Membrane>
SUBCELLULAR LOCATIONCell membrane; Multi-pass membrane protein.
else
SUBCELLULAR LOCATIONMembrane; Multi-pass membrane protein.
end case

Keywords [?]

case <OC:Bacteria> or <OC:Archaea>
Transport
Sugar transport
Phosphotransferase system
Transmembrane
Membrane
end case
case (<OC:Bacteria> or <OC:Archaea>) and defined <Property:Membrane> and <Property:Membrane=2>
Cell inner membrane
end case

Gene Ontology [?]

GO:0051119; Molecular function:sugar transmembrane transporter activity
case <OCellular component:Bacteria> and defined <Property:Membrane> and <Property:Membrane=2>
GO:0005886; Cellular component:plasma membrane
else case <OCellular component:Bacteria> and defined <Property:Membrane> and <Property:Membrane=1>
GO:0005886; Cellular component:plasma membrane
else case <OCellular component:Archaea> and defined <Property:Membrane>
GO:0005886; Cellular component:plasma membrane
else; https://www.ebi.ac.uk/QuickGO/term/else
GO:0016020; Cellular component:membrane
end case

Cross-references [?]

General Transmembrane; -; 6-8;

Features [?]

From: PS51104
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="PTS EIIC type-2 #"

Additional information [?]

Size range 352 amino acids
Related rules none
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]