We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00434
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00434
General rule information
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| Accession | PRU00434 |
| Dates | 22-APR-2005 (Created)
19-NOV-2022 (Last updated, Version 27) |
| Data class | Domain; |
| Predictors |
PROSITE; PS50893; ABC_TRANSPORTER_2 |
Name | ABC transporter family domain |
| Function | Uses the hydrolysis of ATP to energize diverse biological systems |
| Scope(s) |
Eukaryota Bacteria Archaea Plastid Viruses Spbetavirus |
| Example(s) | P02915; P60752; P13569; |
Propagated annotation
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Keywords
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| case not <AnyFeature:MF_00205> | |
| Transport | |
| end case | |
| ATP-binding | |
| Nucleotide-binding | |
| case (<OC:Bacteria> or <OC:Archaea>) and defined <Property:Membrane> and <Property:Membrane=2> and not <AnyFeature:MF_00205> | |
| Cell inner membrane | |
| Cell membrane | |
| Membrane | |
| end case | |
| case not <AnyFeature:MF_00205> | |
| Membrane | |
| end case | |
Gene Ontology
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| case not <AnyFeature:MF_00205> | |
| GO:0043190; Cellular component:ATP-binding cassette (ABC) transporter complex | |
| GO:0006810; Biological process:transport | |
| end case | |
| GO:0005524; Molecular function:ATP binding | |
| GO:0000166; Molecular function:nucleotide binding | |
Cross-references
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| PROSITE | PS00211; ABC_TRANSPORTER_1; 1; |
Features
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| From: PS50893 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="ABC transporter #" | |||||||||
| BINDING | 33 | 40 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
[AG]-x(4)-G-K-[ST] | ||||||||
Additional information
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| Size range | 200-2438 amino acids |
| Related rules |
none |
| Fusion | None |
| Repeats | 1-2 |
| Topology | Not cytoplasmic |
| Comments | Contains ABC cassette but lost transport capability in UvrA subfamily. |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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