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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00439


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00439
General rule information [?]

Accession PRU00439
Dates 06-MAY-2005 (Created)
21-NOV-2019 (Last updated, Version 7)
Data class Domain;
Predictors PROSITE; PS51076; MH2
Name MAD homology domain 2 (MH2)
Function The MH2 domain is responsible for transactivation and mediates phosphorylation-triggered heteromeric assembly between Smad4 and R-Smad.
Scope(s) Eukaryota
Metazoa
Example(s) Q99717;

Propagated annotation [?]

Keywords [?]

case <Feature:PS51076:192-195=S-S-x-S>
Phosphoprotein
end case

Features [?]

From: PS51076
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="MH2 #"
case <Feature:PS51076:192-195=S-S-x-S>
MOD_RES 193 193 /note="Phosphoserine"
MOD_RES 195 195 /note="Phosphoserine"
end case

Additional information [?]

Size range 160-235 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]