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annotation rule: PRU00439

General rule information [?]

Accession PRU00439
Dates 6-MAY-2005 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain
Predictors PROSITE; PS51076; MH2
Name MAD homology domain 2 (MH2)
Function The MH2 domain is responsible for transactivation and mediates phosphorylation-triggered heteromeric assembly between Smad4 and R-Smad.

Propagated annotation [?]

Keywords [?]

case <Feature:PS51076:192-195=S-S-x-S>
end case

Features [?]

From: PS51076
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       MH2 #        
case <Feature:PS51076:192-195=S-S-x-S>
MOD_RES     193     193       Phosphoserine        
MOD_RES     195     195       Phosphoserine        
end case

Additional information [?]

Size range 160-235 amino acids
Related rules None
Repeats 1
Topology Undefined
Example Q99717 (SMAD5_HUMAN)
Eukaryota; Metazoa


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]