ProRule PRU00439

General rule information [?]

Accession PRU00439
Dates 6-MAY-2005 (Created)
21-NOV-2019 (Last updated, Version 6)
Data class Domain;
Predictors PROSITE; PS51076; MH2
Name MAD homology domain 2 (MH2)
Function The MH2 domain is responsible for transactivation and mediates phosphorylation-triggered heteromeric assembly between Smad4 and R-Smad.
Scope(s) Eukaryota
Example(s) Q99717 (SMAD5_HUMAN);

Propagated annotation [?]

Keywords [?]

case <Feature:PS51076:192-195=S-S-x-S>
end case

Features [?]

From: PS51076
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="MH2 #"
case <Feature:PS51076:192-195=S-S-x-S>
MOD_RES 193 193 /note="Phosphoserine"
MOD_RES 195 195 /note="Phosphoserine"
end case

Additional information [?]

Size range 160-235 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

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UniProtKB rule member sequences [?]