ProRule PRU00439
General rule information
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| Accession | PRU00439 |
| Dates | 6-MAY-2005 (Created)
21-NOV-2019 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51076; MH2 |
Name | MAD homology domain 2 (MH2) |
| Function | The MH2 domain is responsible for transactivation and mediates phosphorylation-triggered heteromeric assembly between Smad4 and R-Smad. |
| Scope(s) |
Eukaryota Metazoa |
| Example(s) | Q99717 (SMAD5_HUMAN); |
Propagated annotation
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Keywords
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| case <Feature:PS51076:192-195=S-S-x-S> | |
| Phosphoprotein | |
| end case | |
Features
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| From: PS51076 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="MH2 #" | |||||||||
| case <Feature:PS51076:192-195=S-S-x-S> | ||||||||||||
| MOD_RES | 193 | 193 | /note="Phosphoserine" | |||||||||
| MOD_RES | 195 | 195 | /note="Phosphoserine" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 160-235 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [44] All [ 44 ]
- Retrieve set of proteins with 3D structure for this domain