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ProRule PRU00444


General rule information [?]

PURL https://purl.expasy.org/prosite/rule/PRU00444
Accession PRU00444
Dates 2-JUN-2005 (Created)
19-NOV-2022 (Last updated, Version 16)
Data class Domain;
Predictors PROSITE; PS51124; PEPTIDASE_C16
Name Peptidase family C16 domain
Function Peptidase family C16 contains polyprotein processing endopeptidases from coronaviruses.
Scope(s) Viruses
Example(s) P16342 (R1AB_CVMA5);

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=3.4.22.-;
end case

Keywords [?]

case <FTGroup:1>
Thiol protease
Hydrolase
Protease
end case
Zinc-finger
case <FTGroup:2>
Zinc
Metal-binding
end case
case <Feature:PS51124:117=[C]> and <Feature:PS51124:119=[C]> and <Feature:PS51124:148=[C]> and <Feature:PS51124:150=[C]>
else case <Feature:PS51124:117=[CH]> and <Feature:PS51124:119=[CH]> and <Feature:PS51124:148=[CH]> and <Feature:PS51124:150=[CH]>

Features [?]

From: PS51124
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C16 #"
ACT_SITE 39 39 /note="For PL#1-PRO activity" C 1
ACT_SITE 198 198 /note="For PL#1-PRO activity" H 1
ACT_SITE 211 211 /note="For PL#1-PRO activity" D 1
case <Feature:PS51124:117=[C]> and <Feature:PS51124:119=[C]> and <Feature:PS51124:148=[C]> and <Feature:PS51124:150=[C]>
ZN_FING 117 150 /note="C4-type #"
else case <Feature:PS51124:117=[CH]> and <Feature:PS51124:119=[CH]> and <Feature:PS51124:148=[CH]> and <Feature:PS51124:150=[CH]>
ZN_FING 117 150 /note="C4-type #; atypical"
else
ZN_FING 117 150 /note="C4-type #; degenerate"
end case
BINDING 117 117 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 2
BINDING 119 119 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 2
BINDING 148 148 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 2
BINDING 150 150 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 2

Additional information [?]

Size range 250-260 amino acids
Related rules none
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.



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UniProtKB rule member sequences [?]