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annotation rule: PRU00444

General rule information [?]

Accession PRU00444
Dates 2-JUN-2005 (Created)
20-JUN-2022 (Last updated, Version 15)
Data class Domain
Predictors PROSITE; PS51124; PEPTIDASE_C16
Name Peptidase family C16 domain
Function Peptidase family C16 contains polyprotein processing endopeptidases from coronaviruses.

Propagated annotation [?]


Description [?]

case <FTGroup:1>
+ RecName: EC 3.4.22.-;
end case


Keywords [?]

case <FTGroup:1>
Thiol protease
Hydrolase
Protease
end case

Zinc-finger
case <FTGroup:2>
Zinc
Metal-binding
end case


Features [?]

From: PS51124
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       Peptidase C16 #        
ACT_SITE     39     39       For PL#1-PRO activity     C   1
ACT_SITE     198     198       For PL#1-PRO activity     H   1
ACT_SITE     211     211       For PL#1-PRO activity     D   1
case <Feature:PS51124:117=[C]> and <Feature:PS51124:119=[C]> and <Feature:PS51124:148=[C]> and <Feature:PS51124:150=[C]>
ZN_FING     117     150       C4-type #        
else case <Feature:PS51124:117=[CH]> and <Feature:PS51124:119=[CH]> and <Feature:PS51124:148=[CH]> and <Feature:PS51124:150=[CH]>
ZN_FING     117     150       C4-type #; atypical        
else
ZN_FING     117     150       C4-type #; degenerate        
end case

BINDING     117     117       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     [CH]   2
BINDING     119     119       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     [CH]   2
BINDING     148     148       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     [CH]   2
BINDING     150     150       /ligand="Zn(2+)" /ligand_id="29105" /ligand_label="#1     [CH]   2

Additional information [?]

Size range 250-260 amino acids
Related rules none
Repeats 1-2
Topology Undefined
Example P16342 (R1AB_CVMA5)
Scope
Viruses

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]