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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00444


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00444
General rule information [?]

Accession PRU00444
Dates 02-JUN-2005 (Created)
19-NOV-2022 (Last updated, Version 17)
Data class Domain;
Predictors PROSITE; PS51124; PEPTIDASE_C16
Name Peptidase family C16 domain
Function Peptidase family C16 contains polyprotein processing endopeptidases from coronaviruses.
Scope(s) Viruses
Example(s) P16342;

Propagated annotation [?]

Identifier, protein and gene names [?]

case <FTGroup:1>
Protein name + RecName: EC=3.4.22.-;
end case

Keywords [?]

case <FTGroup:1>
Thiol protease
Hydrolase
Protease
end case
Zinc-finger
case <FTGroup:2>
Zinc
Metal-binding
end case
case <Feature:PS51124:117=[C]> and <Feature:PS51124:119=[C]> and <Feature:PS51124:148=[C]> and <Feature:PS51124:150=[C]>
else case <Feature:PS51124:117=[CH]> and <Feature:PS51124:119=[CH]> and <Feature:PS51124:148=[CH]> and <Feature:PS51124:150=[CH]>

Features [?]

From: PS51124
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Peptidase C16 #"
ACT_SITE 39 39 /note="For PL#1-PRO activity" C 1
ACT_SITE 198 198 /note="For PL#1-PRO activity" H 1
ACT_SITE 211 211 /note="For PL#1-PRO activity" D 1
case <Feature:PS51124:117=[C]> and <Feature:PS51124:119=[C]> and <Feature:PS51124:148=[C]> and <Feature:PS51124:150=[C]>
ZN_FING 117 150 /note="C4-type #"
else case <Feature:PS51124:117=[CH]> and <Feature:PS51124:119=[CH]> and <Feature:PS51124:148=[CH]> and <Feature:PS51124:150=[CH]>
ZN_FING 117 150 /note="C4-type #; atypical"
else
ZN_FING 117 150 /note="C4-type #; degenerate"
end case
BINDING 117 117 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 2
BINDING 119 119 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 2
BINDING 148 148 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 2
BINDING 150 150 /ligand="Zn(2+)"
/ligand_id="ChEBI:CHEBI:29105"
/ligand_label="#1"		 [CH] 2

Additional information [?]

Size range 250-260 amino acids
Related rules none
Fusion None
Repeats 1-2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]