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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00448


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00448
General rule information [?]

Accession PRU00448
Dates 28-JUN-2005 (Created)
19-NOV-2022 (Last updated, Version 16)
Data class Domain;
Predictors PROSITE; PS50222; EF_HAND_2
Name EF-hand
Function Undefined
Scope(s) Eukaryota
Bacteria
Viruses
Example(s) P62157;

Propagated annotation [?]

Keywords [?]

case <FTTag:binds>
Calcium
Metal-binding
end case

Cross-references [?]

PROSITE PS00018; EF_HAND_1; 0-1;

Features [?]

From: PS50222
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="EF-hand #"
case <Feature:PS50222:14-26=D-{W}-[DNS]-{ILVFYW}-[DENSTG]-[DNQGHRK]-{GP}-[LIVMC]-[DENQSTAGC]-x(2)-[DE]-[LIVMFYW]>
BINDING 14 14 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 binds [HCUEDKQNMYWSTRX]
BINDING 16 16 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 binds [HCUEDKQNMYWSTRX]
BINDING 18 18 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 binds [HCUEDKQNMYWSTRX]
BINDING 20 20 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 binds [HCUEDKQNMYWSTRX]
BINDING 25 25 /ligand="Ca(2+)"
/ligand_id="ChEBI:CHEBI:29108"
/ligand_label="#1"		 binds [HCUEDKQNMYWSTRX]
end case

Additional information [?]

Size range 20-45 amino acids
Related rules None
Fusion None
Repeats 1-8
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]