ProRule PRU00512
General rule information
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| PURL | https://purl.expasy.org/prosite/rule/PRU00512 |
| Accession | PRU00512 |
| Dates | 24-NOV-2005 (Created)
27-JUN-2022 (Last updated, Version 11) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51156; ELM2 |
Name | ELM2 domain |
| Function | The ELM2 (EGL-27 and MTA1 homology) domain has been shown to function as a transcriptional repression domain through recruitment of HDAC activity. |
| Scope(s) |
Eukaryota |
| Example(s) | Q9P2K3 (RCOR3_HUMAN); |
Propagated annotation
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Comments
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| SUBCELLULAR LOCATION | Nucleus. |
Keywords
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Gene Ontology
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| GO:0005634; Cellular component:nucleus |
| GO:0006355; Biological process:regulation of DNA-templated transcription |
| GO:0006351; Biological process:DNA-templated transcription |
Features
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| From: PS51156 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="ELM2 #" | |||||||||
Additional information
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| Size range | 85-115 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Not cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [46] All [ 46 ]
- Retrieve set of proteins with 3D structure for this domain