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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00512


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00512
General rule information [?]

Accession PRU00512
Dates 24-NOV-2005 (Created)
27-JUN-2022 (Last updated, Version 12)
Data class Domain;
Predictors PROSITE; PS51156; ELM2
Name ELM2 domain
Function The ELM2 (EGL-27 and MTA1 homology) domain has been shown to function as a transcriptional repression domain through recruitment of HDAC activity.
Scope(s) Eukaryota
Example(s) Q9P2K3;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.

Keywords [?]

Nucleus
Repressor
Transcription
Transcription regulation

Gene Ontology [?]

GO:0005634; Cellular component:nucleus
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Features [?]

From: PS51156
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="ELM2 #"

Additional information [?]

Size range 85-115 amino acids
Related rules None
Fusion None
Repeats 1
Topology Not cytoplasmic

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]