We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00520
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00520
General rule information
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| Accession | PRU00520 |
| Dates | 13-DEC-2005 (Created)
03-SEP-2024 (Last updated, Version 13) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51160; ACYLPHOSPHATASE_3 |
Name | Acylphosphatase-like domain |
| Function | Acylphosphatase (EC 3.6.1.7) [1,2] catalyzes the hydrolysis of various acyl phosphate carboxyl-phosphate bonds such as carbamyl phosphate, succinyl phosphate, 1,3-diphosphoglycerate, etc. |
| Scope(s) |
Eukaryota Bacteria Archaea |
| Example(s) | P0AB65; |
Propagated annotation
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Identifier, protein and gene names
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| case <FTGroup:1> | |
| Protein name | + RecName: EC=3.6.1.7; |
Comments
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| CATALYTIC ACTIVITY | Reaction=an acyl phosphate + H2O = a carboxylate + phosphate + H(+); Xref=Rhea:RHEA:14965, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:29067, ChEBI:CHEBI:43474, ChEBI:CHEBI:59918; EC=3.6.1.7; |
| end case | |
Keywords
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Gene Ontology
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| GO:0016787; Molecular function:hydrolase activity |
Cross-references
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Features
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| From: PS51160 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Acylphosphatase-like #" | |||||||||
| ACT_SITE | 16 | 16 | R | 1 | ||||||||
| ACT_SITE | 34 | 34 | N | 1 | ||||||||
Additional information
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| Size range | 65-100 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [30] Bacteria [232] Eukaryota [21] All [ 283 ]
- Retrieve set of proteins with 3D structure for this domain