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annotation rule: PRU00530

General rule information [?]

Accession PRU00530
Dates 27-JAN-2006 (Created)
27-JUN-2022 (Last updated, Version 11)
Data class Domain
Predictors PROSITE; PS51179; POU_3
Name POU-specific (POUs) domain
Function The POUs domain is always found in association with a POU- homeodomain, and both are required for high affinity and sequence-specific DNA binding.

Propagated annotation [?]


Comments [?]

Subcellular location Nucleus.

Cross-references [?]

PROSITE PS00035; POU_1; 1;
PS00465; POU_2; 1;

Gene Ontology [?]

case <AnyFeature:PS50071>
GO:0003677; Molecular function: DNA binding.
GO:0005634; Cellular component: nucleus.
GO:0006355; Biological process: regulation of DNA-templated transcription.
GO:0006351; Biological process: DNA-templated transcription.

Keywords [?]

DNA-binding
Nucleus
Transcription
Transcription regulation
end case


Features [?]

From: PS51179
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       POU-specific #        

Additional information [?]

Size range 70-115 amino acids
Related rules None
Repeats 1
Topology Undefined
Example P24350 (IPOU_DROME)
Scope
Eukaryota; Metazoa

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.


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UniProtKB rule member sequences [?]