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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00530


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00530
General rule information [?]

Accession PRU00530
Dates 27-JAN-2006 (Created)
27-JUN-2022 (Last updated, Version 12)
Data class Domain;
Predictors PROSITE; PS51179; POU_3
Name POU-specific (POUs) domain
Function The POUs domain is always found in association with a POU- homeodomain, and both are required for high affinity and sequence-specific DNA binding.
Scope(s) Eukaryota
Metazoa
Example(s) P24350;

Propagated annotation [?]

Comments [?]

SUBCELLULAR LOCATIONNucleus.

Keywords [?]

DNA-binding
Nucleus
Transcription
Transcription regulation

Gene Ontology [?]

GO:0003677; Molecular function:DNA binding
GO:0005634; Cellular component:nucleus
GO:0006355; Biological process:regulation of DNA-templated transcription
GO:0006351; Biological process:DNA-templated transcription

Cross-references [?]

PROSITE PS00035; POU_1; 1;
PROSITE PS00465; POU_2; 1;

Features [?]

From: PS51179
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="POU-specific #"

Additional information [?]

Size range 70-115 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]