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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00538


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00538
General rule information [?]

Accession PRU00538
Dates 16-MAR-2006 (Created)
19-NOV-2022 (Last updated, Version 8)
Data class Domain;
Predictors PROSITE; PS51184; JMJC
Name JmjC domain
Function the JmjC domain is found in organisms from bacteria to human and has been shown to function in a histone demethylation mechanism that is conserved from yeast to human.
Scope(s) Eukaryota
Bacteria
Viruses
Example(s) Q9Y4C1;

Propagated annotation [?]

Keywords [?]

case <FTGroup:1>
Iron
Metal-binding
end case

Gene Ontology [?]

case <FTGroup:1>
GO:0046872; Molecular function:metal ion binding
end case

Features [?]

From: PS51184
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="JmjC #"
BINDING 47 47 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_note="catalytic"		 H 1
BINDING 49 49 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_note="catalytic"		 [DE] 1
BINDING 129 129 /ligand="Fe cation"
/ligand_id="ChEBI:CHEBI:24875"
/ligand_note="catalytic"		 [HY] 1

Additional information [?]

Size range 120-230 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]