ProRule PRU00541
General rule information
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Accession | PRU00541 |
Dates | 12-APR-2006 (Created)
19-NOV-2022 (Last updated, Version 10) |
Data class | Domain; |
Predictors |
PROSITE; PS51192; HELICASE_ATP_BIND_1 PROSITE; PS51193; HELICASE_ATP_BIND_2 |
Name | Helicase ATP-binding domain |
Function | Helicase ATP-binding domain in association with helicase C-terminal domain catalyze the separation of double-stranded nucleic acids |
Scope(s) |
Eukaryota Bacteria Archaea Viruses |
Example(s) | Q14240 (IF4A2_HUMAN); |
Propagated annotation
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Keywords
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ATP-binding | |
<a href="https://www.uniprot.org/keywords/KW-0347">Helicase</a> | |
Hydrolase | |
Nucleotide-binding |
Gene Ontology
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GO:0004386; Molecular function:helicase activity |
GO:0005524; Molecular function:ATP binding |
GO:0016787; Molecular function:hydrolase activity |
GO:0000166; Molecular function:nucleotide binding |
Cross-references
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Features
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From: any | ||||||||||||
Key | From | To | Description | Tag | Condition | FTGroup | ||||||
DOMAIN | from | to | /note="Helicase ATP-binding #" | |||||||||
/note="Helicase ATP-binding #" | ||||||||||||
case <Feature:PS51192>=1> | ||||||||||||
BINDING | 14 | 21 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
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end case | ||||||||||||
case <Feature:PS51193>=1> | ||||||||||||
BINDING | 36 | 43 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
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end case | ||||||||||||
case <Feature:PS51192:121=D> | ||||||||||||
MOTIF | 118 | 121 | /note="DEAD box" | |||||||||
end case | ||||||||||||
case <Feature:PS51192:121=H> | ||||||||||||
MOTIF | 118 | 121 | /note="DEAH box" | |||||||||
end case | ||||||||||||
case <Feature:PS51193:234=D> | ||||||||||||
MOTIF | 231 | 234 | /note="DEAD box" | |||||||||
end case | ||||||||||||
case <Feature:PS51193:234=H> | ||||||||||||
MOTIF | 231 | 234 | /note="DEAH box" | |||||||||
end case |
Additional information
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Size range | 120-350 amino acids |
Related rules |
None |
Fusion | None |
Repeats | 2 |
Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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