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ProRule PRU00541


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PURL: https://purl.expasy.org/prosite/rule/PRU00541
General rule information [?]

Accession PRU00541
Dates 12-APR-2006 (Created)
20-MAY-2025 (Last updated, Version 12)
Data class Domain;
Predictors PROSITE; PS51192; HELICASE_ATP_BIND_1
PROSITE; PS51193; HELICASE_ATP_BIND_2
Name Helicase ATP-binding domain
Function Helicase ATP-binding domain in association with helicase C-terminal domain catalyze the separation of double-stranded nucleic acids
Scope(s) Eukaryota
Bacteria
Archaea
Viruses
Example(s) Q14240 (IF4A2_HUMAN);

Propagated annotation [?]

Keywords [?]

ATP-binding
Hydrolase
Nucleotide-binding

Gene Ontology [?]

GO:0005524; Molecular function:ATP binding
GO:0016787; Molecular function:hydrolase activity
GO:0000166; Molecular function:nucleotide binding

Cross-references [?]

PROSITE PS00039; DEAD_ATP_HELICASE; 0-1;
PROSITE PS00690; DEAH_ATP_HELICASE; 0-1;

Features [?]

From: any
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="Helicase ATP-binding #"
case <Feature:PS51192>=1>
BINDING 14 21 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
end case
case <Feature:PS51193>=1>
BINDING 36 43 /ligand="ATP"
/ligand_id="ChEBI:CHEBI:30616"
end case
case <Feature:PS51192:121=D>
MOTIF 118 121 /note="DEAD box"
end case
case <Feature:PS51192:121=H>
MOTIF 118 121 /note="DEAH box"
end case
case <Feature:PS51193:234=D>
MOTIF 231 234 /note="DEAD box"
end case
case <Feature:PS51193:234=H>
MOTIF 231 234 /note="DEAH box"
end case

Additional information [?]

Size range 120-350 amino acids
Related rules None
Fusion None
Repeats 2
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]