We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00541
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00541
General rule information
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| Accession | PRU00541 |
| Dates | 12-APR-2006 (Created)
20-MAY-2025 (Last updated, Version 12) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51192; HELICASE_ATP_BIND_1 PROSITE; PS51193; HELICASE_ATP_BIND_2 |
Name | Helicase ATP-binding domain |
| Function | Helicase ATP-binding domain in association with helicase C-terminal domain catalyze the separation of double-stranded nucleic acids |
| Scope(s) |
Eukaryota Bacteria Archaea Viruses |
| Example(s) | Q14240; |
Propagated annotation
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Keywords
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Gene Ontology
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| GO:0005524; Molecular function:ATP binding |
| GO:0016787; Molecular function:hydrolase activity |
| GO:0000166; Molecular function:nucleotide binding |
Cross-references
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Features
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| From: any | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="Helicase ATP-binding #" | |||||||||
| case <Feature:PS51192>=1> | ||||||||||||
| BINDING | 14 | 21 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
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| end case | ||||||||||||
| case <Feature:PS51193>=1> | ||||||||||||
| BINDING | 36 | 43 | /ligand="ATP" /ligand_id="ChEBI:CHEBI:30616" |
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| end case | ||||||||||||
| case <Feature:PS51192:121=D> | ||||||||||||
| MOTIF | 118 | 121 | /note="DEAD box" | |||||||||
| end case | ||||||||||||
| case <Feature:PS51192:121=H> | ||||||||||||
| MOTIF | 118 | 121 | /note="DEAH box" | |||||||||
| end case | ||||||||||||
| case <Feature:PS51193:234=D> | ||||||||||||
| MOTIF | 231 | 234 | /note="DEAD box" | |||||||||
| end case | ||||||||||||
| case <Feature:PS51193:234=H> | ||||||||||||
| MOTIF | 231 | 234 | /note="DEAH box" | |||||||||
| end case | ||||||||||||
Additional information
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| Size range | 120-350 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 2 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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