We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00544
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00544
General rule information
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| Accession | PRU00544 |
| Dates | 26-APR-2006 (Created)
21-NOV-2019 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51202; RCK_C |
Name | RCK C-terminal domain |
| Function | The C-terminal part of the regulators of K+ conductance (RCK) domain is less conserved among RCK domains, being absent in some. It is predicted to bind unidentified ligands and to regulate sulfate, sodium and other transporters. It forms an extention of the dimer interface and further stabilizes the RCK homodimer. |
| Scope(s) |
Bacteria Archaea Eukaryota |
| Example(s) | P0AGI8; |
Propagated annotation
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Gene Ontology
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| GO:0043266; Biological process:regulation of potassium ion transport |
| GO:0015459; Molecular function:potassium channel regulator activity |
Cross-references
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| PROSITE | PS51202; RCK_C; 1-4; |
Features
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| From: PS51202 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="RCK C-terminal #" | |||||||||
Additional information
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| Size range | 75-100 amino acids |
| Related rules |
none |
| Fusion | None |
| Repeats | 1-4 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Archaea [12] Bacteria [295] Eukaryota [4] All [ 311 ]
- Retrieve set of proteins with 3D structure for this domain