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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

ProRule PRU00550


View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00550
General rule information [?]

Accession PRU00550
Dates 09-MAY-2006 (Created)
21-NOV-2019 (Last updated, Version 4)
Data class Domain;
Predictors PROSITE; PS51205; VPS9
Name VPS9 domain
Function The VPS9 domain is a GDP-GTP exchange factor (GEF) domain that catalyzes nucleotide exchange on Rab5, which activates this Rab GTPase.
Scope(s) Eukaryota
Example(s) Q8TB24;

Propagated annotation [?]

Keywords [?]

GTPase activation

Gene Ontology [?]

GO:0005096; Molecular function:GTPase activator activity

Features [?]

From: PS51205
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="VPS9 #"

Additional information [?]

Size range 130-170 amino acids
Related rules None
Fusion None
Repeats 1
Topology Undefined

Copyright

PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]