We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
ProRule PRU00568
View rule in raw text format (no links)
PURL: https://purl.expasy.org/prosite/rule/PRU00568
General rule information
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| Accession | PRU00568 |
| Dates | 29-JUN-2006 (Created)
21-NOV-2019 (Last updated, Version 6) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51221; TTL |
Name | TTL domain |
| Function | The TTL (tubulin tyrosine ligase) domain is a ~350 amino acid module present in a family of eukaryotic proteins that could catalyze ligations of diverse amino acids to tubulins or other substrates. |
| Scope(s) |
Eukaryota |
| Example(s) | Q8NG68; |
Propagated annotation
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Identifier, protein and gene names
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| Protein name | + RecName: EC=6.-.-.-; |
Keywords
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Gene Ontology
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| GO:0016874; Molecular function:ligase activity |
Features
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| From: PS51221 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="TTL #" | |||||||||
Additional information
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| Size range | 330-400 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Undefined |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [63] All [ 63 ]
- Retrieve set of proteins with 3D structure for this domain