ProRule PRU00579

General rule information [?]

Accession PRU00579
Dates 16-OCT-2006 (Created)
21-NOV-2019 (Last updated, Version 3)
Data class Domain;
Predictors PROSITE; PS51232; GBD_FH3
Name Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
Function The GBD/FH3 domain is approximately 380 residues in length. Its role appears to be twofold. On one hand the N-terminal region of formins is involved in subcellular localization through interaction with diverse targets. On the other hand the GBD/FH3 domain is involved in regulation of activation by releasing of an intramolecular interaction between the DAD and the N-terminus.
Scope(s) Eukaryota
Example(s) Q9Y4D1 (DAAM1_HUMAN);

Propagated annotation [?]

Features [?]

From: PS51232
Key From To Description Tag Condition FTGroup
DOMAIN from to /note="GBD/FH3 #"

Additional information [?]

Size range 360-525 amino acids
Related rules None
Fusion None
Repeats 1
Topology Cytoplasmic


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UniProtKB rule member sequences [?]