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annotation rule: PRU00579

General rule information [?]

Accession PRU00579
Dates 16-OCT-2006 (Created)
21-NOV-2019 (Last updated, Version 3)
Data class Domain
Predictors PROSITE; PS51232; GBD_FH3
Name Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
Function The GBD/FH3 domain is approximately 380 residues in length. Its role appears to be twofold. On one hand the N-terminal region of formins is involved in subcellular localization through interaction with diverse targets. On the other hand the GBD/FH3 domain is involved in regulation of activation by releasing of an intramolecular interaction between the DAD and the N-terminus.

Propagated annotation [?]

Features [?]

From: PS51232
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       GBD/FH3 #        

Additional information [?]

Size range 360-525 amino acids
Related rules None
Repeats 1
Topology Cytoplasmic
Example Q9Y4D1 (DAAM1_HUMAN)


PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.

UniProtKB rule member sequences [?]