ProRule PRU00579
General rule information
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| Accession | PRU00579 |
| Dates | 16-OCT-2006 (Created)
21-NOV-2019 (Last updated, Version 3) |
| Data class | Domain; |
| Predictors |
PROSITE; PS51232; GBD_FH3 |
Name | Rho GTPase-binding/formin homology 3 (GBD/FH3) domain |
| Function | The GBD/FH3 domain is approximately 380 residues in length. Its role appears to be twofold. On one hand the N-terminal region of formins is involved in subcellular localization through interaction with diverse targets. On the other hand the GBD/FH3 domain is involved in regulation of activation by releasing of an intramolecular interaction between the DAD and the N-terminus. |
| Scope(s) |
Eukaryota |
| Example(s) | Q9Y4D1 (DAAM1_HUMAN); |
Propagated annotation
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Features
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| From: PS51232 | ||||||||||||
| Key | From | To | Description | Tag | Condition | FTGroup | ||||||
| DOMAIN | from | to | /note="GBD/FH3 #" | |||||||||
Additional information
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| Size range | 360-525 amino acids |
| Related rules |
None |
| Fusion | None |
| Repeats | 1 |
| Topology | Cytoplasmic |
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see prosite_license.html.
UniProtKB rule member sequences
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- UniProtKB/Swiss-Prot sets
Eukaryota [52] All [ 52 ]
- Retrieve set of proteins with 3D structure for this domain