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annotation rule: PRU00579

General rule information [?]

Accession PRU00579
Dates 16-OCT-2006 (Created)
19-DEC-2016 (Last updated, Version 2)
Data class Domain
Predictors PROSITE; PS51232; GBD_FH3
Name Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
Function The GBD/FH3 domain is approximately 380 residues in length. Its role appears to be twofold. On one hand the N-terminal region of formins is involved in subcellular localization through interaction with diverse targets. On the other hand the GBD/FH3 domain is involved in regulation of activation by releasing of an intramolecular interaction between the DAD and the N-terminus.

Propagated annotation [?]


Features [?]

From: PS51232
Key     From     To       Description   Tag   Condition   FTGroup
DOMAIN     from     to       GBD/FH3 #        

Additional information [?]

Size range 360-525 amino acids
Related rules None
Repeats 1
Topology Cytoplasmic
Example Q9Y4D1 (DAAM1_HUMAN)
Scope
Eukaryota

Copyright

PROSITE is copyright. It is produced by the SIB Swiss Institute Bioinformatics. There are no restrictions on its use by non-profit institutions as long as its content is in no way modified. Usage by and for commercial entities requires a license agreement. For information about the licensing scheme send an email to license@isb-sib.ch or see: prosite_license.html.



UniProtKB rule member sequences [?]